Bariatric Surgery Clinical Trial
Official title:
Physiological Responses to Laparoscopic Sleeve Gastrectomy: Focusing on Ghrelin
Our hypothesis is that decreased concentration of ghrelin after LSG is important for the decreased appetite and food intake postoperatively. We therefore expect infusion of ghrelin will increase an ad libitum food intake after LSG. We also expect that a decreased postprandial concentration of ghrelin after LSG play a role for increased insulin secretion and decreased postprandial plasma glucose concentrations after surgery.
Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are to bariatric procedure. After both procedures, a changed secretion of hormones from the gastrointestinal tract is believed to affect appetite and glucose metabolism. Studies have shown that after LRYGB, there is a significant increased secretion of GLP-1 and PYY. In contrast, a decreased secretion of ghrelin is a characteristic finding after LSG opposite post-LRYGB, where secretion of ghrelin is reported to be increased, decreased or unchanged. Ghrelin is primarily secreted from the gastric mucosa in the fasting state and decreases in response to food intake. Ghrelin stimulates food intake through appetite-regulating centers in the hypothalamus. Administration of exogenous ghrelin has been reported to stimulate appetite. In addition, ghrelin has recently been suggested also to affect glucose metabolism by inhibition of glucose-stimulated insulin secretion. Therefore the markedly decreased secretion of ghrelin could be of particular important for the decreased appetite and improved glucose tolerance seen after LSG. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT04517591 -
Reducing Sedentary Time in Bariatric: The Take a STAND for Health Study
|
N/A | |
| Active, not recruiting |
NCT04433338 -
The PREBA Study: Effect of Preoperative Weight Loss With a 14-day Low-calorie Diet on Surgical Procedure and Outcomes in Patients Undergoing RYGB Surgery
|
N/A | |
| Completed |
NCT05854875 -
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
|
N/A | |
| Recruiting |
NCT06460233 -
Blood Pressure Changes After Bariatric Surgery
|
||
| Completed |
NCT00535600 -
Effects of Bariatric Surgery on Insulin
|
||
| Withdrawn |
NCT04771247 -
Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy
|
N/A | |
| Not yet recruiting |
NCT03203161 -
Registry on Obesity Surgery in Adolescents
|
||
| Enrolling by invitation |
NCT02552433 -
Complications in Body Contouring Surgery
|
||
| Completed |
NCT02525016 -
Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery
|
Phase 3 | |
| Recruiting |
NCT01984762 -
Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in the Treatment of Type 2 Diabetes Mellitus.
|
N/A | |
| Not yet recruiting |
NCT01652105 -
Randomized Trial of Preoperative Diets Before Bariatric Surgery
|
N/A | |
| Completed |
NCT00989157 -
Effects of Gastric Bypass on Blood Levels of Duloxetine
|
Phase 3 | |
| Completed |
NCT03609632 -
Understanding Hypoglycaemia After Bariatric Surgery
|
N/A | |
| Completed |
NCT05454696 -
Online Clinic Pilates Exercises in Patients Undergoing Bariatric Surgery
|
N/A | |
| Completed |
NCT04040647 -
Tolerance of Early Postoperative Mobilization and Ambulation
|
||
| Recruiting |
NCT04297306 -
Virtual Reality Exercise Gaming in Patients Awaiting Bariatric Surgery
|
N/A | |
| Recruiting |
NCT05428618 -
Mobile Application for Bariatric Surgery Patients
|
N/A | |
| Not yet recruiting |
NCT03975244 -
Semi-supervised Exercise Program Before Bariatric Surgery
|
N/A | |
| Not yet recruiting |
NCT03900481 -
Use of an Endoluminal-suturing Device for Endoscopic Gastric Reduction as an Aid for Class I Obesity, or Class II Obesity Without Comorbidity
|
N/A | |
| Recruiting |
NCT06157606 -
Prediction Model for Inadequate Weight Loss After Sleeve Gastrectomy
|