Bariatric Surgery Clinical Trial
Official title:
The Impact of Bariatric Surgery on Estimated Liver Function in Chinese Obesity Patients: a Retrospective Cohort Study
Verified date | September 2018 |
Source | First Affiliated Hospital of Jinan University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Obesity and related metabolic diseases have become a chronic disease that is a threat to
human health. Bariatric surgery can effectively and long-term reduce excess body weight and
relieve related metabolic diseases, including type 2 diabetes. Laparoscopic gastric bypass
surgery and laparoscopic sleeve gastrectomy are commonly used in bariatric surgery.
Laparoscopic sleeve gastrectomy due to simple operation, good weight loss, and metabolic
disease control effect, which is more widely used. However, there are several studies that
show an increased chance of gastroesophageal reflux disease after laparoscopic sleeve
gastrectomy. Long-term gastroesophageal reflux may lead to Barrett's esophagus or esophageal
cancer. Nowadays, the cause of gastroesophageal reflux disease after sleeve gastrectomy is
not clear and precautionary measures are not precise.
In this study, prospective randomized controlled trials were conducted to explore the
possible causes of liver funnction after bariatric surgery and to explore ways to prevent
liver functione after bariatric surgery
Status | Active, not recruiting |
Enrollment | 1000 |
Est. completion date | December 2019 |
Est. primary completion date | December 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - For the choice of surgical approach, numerous studies have shown that BMI ? 45, the general choice of gastric bypass surgery, BMI <45, you can choose sleeve gastrectomy. The remission rate for T2DM, sleeve gastrectomy has a good result for young patients with shorter duration. In the investigator's country, the BMI less than 45 is majorities. Exclusion Criteria: - BMI<27.5 |
Country | Name | City | State |
---|---|---|---|
China | The frist affiliated hospital of Jinan University | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
First Affiliated Hospital of Jinan University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | preoperative of aminotransferase aspartate | Aminotransferase aspartate in U/L | Preoperative | |
Primary | Postoperative of aminotransferase aspartate at 3 months | Aminotransferase aspartate in U/L | 3 months | |
Primary | Postoperative of aminotransferase aspartate at 6 months | Aminotransferase aspartate in U/L | 6 months | |
Primary | Postoperative of aminotransferase aspartate at 1 year | Aminotransferase aspartate in U/L | 1 year | |
Secondary | preoperative of alanine aminotransferase | Alanine aminotransferase in U/L | Preoperative | |
Secondary | Postoperative of alanine aminotransferase at 3 months | Alanine aminotransferase in U/L | 3 months | |
Secondary | Postoperative of alanine aminotransferase at 6 months | Alanine aminotransferase in U/L | 6 months | |
Secondary | Postoperative of alanine aminotransferase at 1 year | Alanine aminotransferase in U/L | 1 year |
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