Bariatric Surgery Patients Clinical Trial
Official title:
Cognitive Effects of Bariatric Surgery
There is growing evidence that obesity is associated with adverse neurocognitive outcome.
Recent studies demonstrate that elevated body mass index (BMI) is an independent risk factor
for Alzheimer's disease, structural brain abnormalities, and cognitive dysfunction in older
adults. Preliminary work from our lab extends these findings and shows structural brain
differences and cognitive dysfunction also exist in obese young and middle-aged adults.
Bariatric surgery is increasingly viewed as an effective intervention for morbid obesity,
though its effects on cognition are unknown. Post-operative nutritional deficiencies are
common and can adversely impact cognitive performance. However, substantial weight loss
resolves or improves many medical conditions with reversible cognitive effects, suggesting
bariatric surgery may provide cognitive benefits.
No study to date has examined the cognitive effects of bariatric surgery. To do so, the
proposed study will prospectively assess cognitive performance in 125 bariatric surgery
patients enrolled in the Longitudinal Assessment of Bariatric Surgery (LABS) project and 125
matched controls. Bariatric surgery patients will complete a computerized cognitive test
battery at four time points: pre-operatively, 12 weeks post-operatively, 12 months
post-operatively, and 24 months post-operatively. Matched control participants will complete
the test battery at similar intervals. Demographic, medical, and psychosocial information
will be collected to elucidate possible mechanisms of change. We hypothesize that the
substantial weight loss following bariatric surgery will be associated with improved
cognitive performance.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05632718 -
Is Resistance Exercise More Effective Than Endurance in Reducing Obesity Relapse in Post-bariatric Surgery Patients
|
N/A |