Bariatric Surgery Candidate Clinical Trial
Official title:
Early Changes of Diabetes Parameters After Obesity Therapy
The aim of the study is to investigate, if bariatric surgery or the related caloric restriction causes the significant improvement of glucose metabolism, which has been found in bariatric patients.
Previous studies have shown, that laparoscopic Roux-en-Y gastric bypass (LRYGB), and also
laparoscopic sleeve gastrectomy (LSG) leed to a significant improvement of glucose metabolism
and in many cases to a complete remission of diabetes type II in obese patients. It is still
unclear which mechanisms underlie these changes. Since the positive effects of bariatric
surgery have been investigated within few days after surgical intervention, before
significant weight loss has been achieved, the caloric restriction has been discussed as a
possible mechanism.
The aim of the study is to investigate, if bariatric surgery or the related caloric
restriction causes the significant improvement of glucose metabolism, which has been found in
bariatric patients. Therefore, the investigator will examine obese patients with diabetes
type II or impaired glucose metabolism regarding possible metabolic changes within few days
after bariatric surgery (LSG or LRYGB) or caloric restriction only.
Group I: Patients undergoing LSG; Group II: Patients undergoing LRYGB; Group III (Control
group): Patients undergoing caloric restriction;
Dietetic, anthropometric, metabolic and hormonal parameters will be measured. Primary outcome
marker is the insulin sensitivity according to Matsuda (MISI).
The project is a prospective, controlled study. Study examinations will be performed before
intervention, and one, two, three, four and five days after (start of) intervention, as well
after one month.
;
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