PERG and mfPERG in Band Atrophy

Band Atrophy Clinical Trial

Official title:

Pattern Electroretinogram and Multifocal Pattern Electroretinogram For the Detection of Neural Loss in Patients With Permanent Temporal Visual Field Defect From Chiasmal Compression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00553761
• Other study ID #: 654/06
• Secondary ID: FAPESP 06/61549-
• Status: Completed
• Phase: N/A
• First received: November 5, 2007
• Last updated: August 4, 2011
• Start date: August 2006
• Est. completion date: July 2009

Study information

• Verified date: November 2007
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Observational

Clinical Trial Summary

The study is designed to evaluate the ability of pattern electroretinogram (PERG) and multifocal pattern electroretinogram (mfPERG) to measure and identify the pattern of band atrophy of the optic nerve in patients with long standing chiasmal lesions. The hypothesis is that these electrophysiological tests were able to identify this such pattern. The idea is to investigate the ability of the these electrophysiological technics in detecting the neural loss from chiasmal compression and to evaluate the ability of PERG and mfPERG parameters to differentiate between eyes with band atrophy of the optic nerve and healthy eyes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: July 2009
• Est. primary completion date: July 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Visual acuity better than 20/30

2. Refractive error less 5 spherical diopter and 3 cylinder diopter

3. Temporal field defect

Exclusion Criteria:

1. Presence of glaucoma and optic nerve anomalies

2. Anormal nasal field

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Atrophy
• Band Atrophy

Intervention

Device:
• Pattern electroretinogram
Full field and hemifield (nasal and temporal) stimulation transient pattern electroretinogram (PERG) were recorded both in patients and controls.

Locations

Country	Name	City	State
Brazil	Universidade de São Paulo	São Paulo

Sponsors (2)

Lead Sponsor	Collaborator
University of Sao Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

External Links

•   Pattern Electroretinograms For the Detection of Neural Loss in Patients with Permanent Temporal Visual Field Defect from Chiasmal Compression