Bacteremia Clinical Trial
Official title:
Recurrent ESBL-producing Enterobacteriaceae Bacteremia: Risk Factor, Molecular Character and Susceptibility Change
The purpose of this study is to investigate the risk factor, molecular character and susceptibility change for recurrent ESBL-producing Enterobacteriaceae bacteremia
1. To characterize the genotypes of the pathogens isolated from recurrent ESBL-EK
bacteremia versus non-recurrent ESBL-EK bacteremia to differentiate relapse from
reinfection
- recurrent versus non-recurrent
- relapse versus reinfection
2. To correlate the patient characteristics, clinical manifestations, severity of illness
(the modified Pitt bacteremia score), diagnosis of deep-site infection, co-morbid
conditions (including diabetes mellitus, hepatic and renal dysfunction), length of stay
in ICU/hospitalization, the presence of invasive procedures, source of pathogen
(community acquired or nosocomial infection), antimicrobial regimen (i.e carbapenems
versus non-carbapenems(flomoxef or quinolones), microbiological characteristics (E coli
and Kleb. pneumoniae) and outcome endpoints (clinical outcome and mortality) with ESBL
recurrence and genotypes
;
Observational Model: Case Control, Time Perspective: Retrospective
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