Back Pain Clinical Trial
Official title:
Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain
The purpose of the research is to collect and examine spinal disc and ligament tissues to see if there are any biological markers that can be correlated with MRI images to help us learn more about causes of back pain. Spinal discs are the pillow-like cushions between the bones of the spine. They act as shock-absorbers for the spine. Spinal ligaments support the disc structure during movement.
Degenerative disc disease is the most prevalent indication for spine surgery and the major source of back pain in afflicted patients. Age related degeneration of the intervertebral discs is not the exception, but the rule. Degenerative changes are associated with weakening of the disc and hypertrophy of the ligamentum flavum in the spine. The aim of this study is to determine if there are any local or systemic biomarkers that correlate with the severity of degeneration as indicated by radiological examination. To date, Imaging (XRay, MRI, CT scans) are the most widely used diagnostic tools for identifying degenerated discs. Physical changes in the disc are also associated with increased secretion and expression of inflammatory mediators in the tissue. The investigators are interested in measuring both gene and protein level changes of inflammatory mediators in degenerated discs in order to correlate these levels with imaging based indicators of degeneration. Protein level changes in the disc and ligamentum flavum have yet to be correlated with MRI-derived disc modic changes classification system. The investigators hypothesize that as the image characteristics of advancing degenerative disease increase, a corresponding change will be present in the secretion (or expression) of specific markers related to inflammatory processes in the disc. Cytokines found to be upregulated in disc tissue or ligamentum flavum will also be measured in patient's serum levels to begin developing a systemic diagnostic method for detecting disc degeneration. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05982483 -
Erector Spinae Plane Block vs. Usual Care for ED Patients With Mechanical Back Pain
|
N/A | |
| Completed |
NCT04744246 -
Muscle Activity During Load Carriage in ROTC Cadets
|
N/A | |
| Completed |
NCT03273114 -
Cognitive Functional Therapy (CFT) Compared With Core Training Exercise and Manual Therapy (CORE-MT) in Patients With Chronic Low Back Pain
|
N/A | |
| Active, not recruiting |
NCT03680846 -
Comparison of HF10 Therapy Combined With CMM to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain
|
N/A | |
| Completed |
NCT05597189 -
Clinical Study for Palliative/Preventive Treatment of Chronic Back Pain
|
N/A | |
| Completed |
NCT05342181 -
Static and Dynamic Core Stability Exercises in Potpartum Back Pain
|
N/A | |
| Completed |
NCT02955342 -
Back and Neck Pain in Adolescence
|
||
| Completed |
NCT02704845 -
Biopsychosocial Exploration of Pain Profiles in Inflammatory and Chronic Non-specific Axial Low Back Pain
|
N/A | |
| Not yet recruiting |
NCT02536274 -
"Examination of the Impact of a Dynamic Flexion Orthosis (Dynaflex®Ottobock) or of a Back Bandage (Lumbo Sensa®Ottobock) on the Voluntary Activation of the Back Muscles in Patients With Specific Back Pain"
|
N/A | |
| Recruiting |
NCT02237105 -
The Effect of Cognitive Behavioral Therapy on the Outcome of Spinal Surgery
|
N/A | |
| Enrolling by invitation |
NCT02485795 -
Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management
|
N/A | |
| Completed |
NCT02609009 -
Back Pain and Spinal Manipulation in Adolescent Scoliosis
|
N/A | |
| Completed |
NCT02254694 -
The Influence of High Heeled Shoes on the Sagittal Balance of the Spine and Whole Body
|
N/A | |
| Terminated |
NCT02239627 -
Epidural Clonidine Versus Corticosteroid for Low Back Pain
|
N/A | |
| Completed |
NCT00986180 -
NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain
|
Phase 3 | |
| Completed |
NCT00771758 -
Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis
|
Phase 3 | |
| Terminated |
NCT00769626 -
Standardizing Management of Patients With Low Back Pain in Primary Care and Physical Therapy
|
Phase 3 | |
| Withdrawn |
NCT00231374 -
Measure of Cerebrospinal Fluid (CSF) Pressure Variation With Patient Positioning
|
N/A | |
| Completed |
NCT00103675 -
Sensor Measurement of Acupuncture Needle Manipulation
|
Phase 1 | |
| Completed |
NCT00454064 -
Cognitive-behavioural Treatment of Chronic Back Pain
|
Phase 3 |