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Clinical Trial Summary

Open-label, dose-escalation study in subjects with previously treated B-cell malignancies to find maximum tolerated dose (MTD) or pharmacologic active dose of a PI3Kδ inhibitor, parsaclisib, as monotherapy and in combination with: itacitinib (INCB039110), a JAK1 inhibitor; rituximab; and rituximab, ifosfamide, carboplatin, and etoposide. Parsaclisib inhibits PI3Kδ, a protein involved in growth and survival of B-cell cancer cells.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02018861
Study type Interventional
Source Incyte Corporation
Contact
Status Completed
Phase Phase 1/Phase 2
Start date September 22, 2016
Completion date April 12, 2021

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