The Human Microbiome in Immune-Mediated Diseases

Status Completed

Clinical Trial Summary

The immune system is influenced by the commensal microbes that live in the gut and on the skin. This study aims to characterize the microbiota of subjects with autoimmune disease in order to determine whether certain microbial species may cause or worsen immune-mediated diseases

Clinical Trial Description

This is a combination of a defined pilot microbiome study as well as exploratory mechanistic research with candidate commensals identified based on known structures accessible in public databases. In the observational prospective two-center study, subjects will be followed for 8 weeks. The study will consist of a total of 3 study visits (0, 4 and 8 weeks). Screening and baseline visits (week 0) will take place at the same time. A study window period of +/- 7 days will be allowed for follow-up study visits. The mechanistic in vitro research with subjects' blood cells and candidate commensals will typically require between 2-4 visits for sampling, but will not be limited by the frequency of visits. ;

Study Design

Related Conditions & MeSH terms

Autoimmune

Clinical Trial Details

NCT number	NCT02394964
Study type	Observational
Source	Yale University
Contact
Status	Completed
Phase
Start date	November 2014
Completion date	December 2023

View Details

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