Autoimmune Diseases Clinical Trial
Official title:
Identification of the Mechanisms of Action of Intravenous Immunoglobulins in CIDP by Analysis of the Genetic Expression Profile in Blood Mononuclear Cells
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder of peripheral nerves. Intravenous immunoglobulins (IVIg) are a first line therapy for CIDP. The investigators used a transcriptomic approach to compare the gene expression profiles in the peripheral blood of patients having a CIDP or autoimmune diseases, before and after IVIg treatment, in order to identify their mechanism of action in this condition, to lead to a better understanding of CIDP pathophysiology, and potentially determine factors associated with the response to the treatment.
We study the change of the:
- gene profile on transcriptome analysis of peripheral blood
- T cell repertory
- igG dosage
- immunological profile
Before IVIG (T1 time) and and 3 weeks after IVIg treatment (T2 time). On a population of
patients having: CIDP, autoimmune muscular disease, Clarkson syndrome, or autoimmune
diseases.
We also search for polymorphism of FCgammareceptor, TKPC et CASP3 genes in CIDP patients
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