Autoimmune Diseases Clinical Trial
Official title:
Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy: a Prospective, Uncontrolled Pilot Study
The aim of this study is to evaluate the effects of subantimicrobial dose doxycycline (50 mg/d), administered for 12 wk, for patients with active moderate-severe Graves' Orbitopathy (GO).
Graves'orbitopathy is an autoimmune disease characterised by an inflammatory phase followed
by fibrosis. Surgery to correct eyelid swelling, proptosis, and diplopia is effective, but
can not be done until the inflammatory phase has passed. To arrest the inflammatory phase,
several types of immunosuppressive treatments have been investigated. Corticosteroids are
the first-choice immunosuppressive treatment, but they often cause severe side-effects.
Subantimicrobial dose doxycycline posses known anti-inflammatory effects that are separate
from their antibacterial mode of action. This mode of action has lead to the routine use of
subantimicrobial dose doxycycline for rosacea, periodontitis and multiple sclerosis.
We propose to test the effect of subantimicrobial dose doxycycline for non-sight
threatening, moderate-severe, inflammatory GO.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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