Autistic Disorder Clinical Trial
Official title:
Diffusion Tensor Imaging in Autism
Verified date | March 2015 |
Source | University of Florida |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Interventional |
Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed
in our lab, the investigators hope to learn more about irregularities in the brain that are
related to autism. The investigators are especially interested in brain regions that
contribute to repetitive behaviors in children with autism. Repetitive behaviors include
stereotyped motor movements (hand-flapping), self-injurious behaviors (head hitting),
compulsions (lining up toys), insistence on things staying the same, and difficulty with
change. These behaviors often interfere with learning, can disrupt daily functioning, and
can lead to other behavioral problems. Two specific aims will be accomplished:
Aim 1: To examine the integrity of white matter pathways in high functioning autistic
children. The investigators hypothesize that autism is associated with specific white matter
abnormalities in the cerebellum and other motor circuits. Additionally, the investigators
expect to confirm and expand on previous reports of cerebral abnormalities by using newly
developed DTI methods.
Aim 2: To determine whether there is a relationship between white matter abnormalities and
the occurrence of restricted repetitive behaviors in children with autism. The investigators
hypothesize that differences in the occurrence and type of restricted repetitive behaviors
between autistic individuals are correlated with specific regional white matter
abnormalities.
Results from the proposed experiments should contribute to current knowledge of brain
abnormalities in autism and their relationship to restricted repetitive behaviors, and may
be relevant to understanding the mechanisms underlying motor deficits in this disorder.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | July 2009 |
Est. primary completion date | July 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 8 Years to 12 Years |
Eligibility |
Inclusion Criteria: - male, aged 8-12 years of age - clinical diagnoses of autism from a licensed professional for Autism or Asperger's Syndrome - IQ >80 - no speech delay - no major sensory or motor deficits Exclusion Criteria: - known genetic or medical conditions (e.g. Fragile X syndrome, tuberous sclerosis, Turner's syndrome) - currently (within prior 3 months) taking anti-psychotic/dopamine-modulating medications |
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research
Country | Name | City | State |
---|---|---|---|
United States | McKnight Brain Institute of the University of Florida | Gainesville | Florida |
Lead Sponsor | Collaborator |
---|---|
University of Florida |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | RBS-R scores, including both total and subset scores | once | No |
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