Autistic Disorder Clinical Trial
Official title:
Diffusion Tensor Imaging in Autism
Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed
in our lab, the investigators hope to learn more about irregularities in the brain that are
related to autism. The investigators are especially interested in brain regions that
contribute to repetitive behaviors in children with autism. Repetitive behaviors include
stereotyped motor movements (hand-flapping), self-injurious behaviors (head hitting),
compulsions (lining up toys), insistence on things staying the same, and difficulty with
change. These behaviors often interfere with learning, can disrupt daily functioning, and
can lead to other behavioral problems. Two specific aims will be accomplished:
Aim 1: To examine the integrity of white matter pathways in high functioning autistic
children. The investigators hypothesize that autism is associated with specific white matter
abnormalities in the cerebellum and other motor circuits. Additionally, the investigators
expect to confirm and expand on previous reports of cerebral abnormalities by using newly
developed DTI methods.
Aim 2: To determine whether there is a relationship between white matter abnormalities and
the occurrence of restricted repetitive behaviors in children with autism. The investigators
hypothesize that differences in the occurrence and type of restricted repetitive behaviors
between autistic individuals are correlated with specific regional white matter
abnormalities.
Results from the proposed experiments should contribute to current knowledge of brain
abnormalities in autism and their relationship to restricted repetitive behaviors, and may
be relevant to understanding the mechanisms underlying motor deficits in this disorder.
Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed in our lab, the investigators aim to confirm and expand upon previous findings of white matter abnormalities throughout the brain in individuals with autism. The investigators have chosen to focus particularly on cerebellar and motor pathways in consideration of the prevalence of motor deficits in autism as well as brain structural studies that have indicated cerebellar abnormalities in autistic children. Finally, a proposal to investigate a possible functional association between white matter structure and the expression of restricted repetitive behaviors in autistic children, by correlating measures of white matter integrity with behavioral assessments indicating the severity of various forms of restricted repetitive behaviors. Two specific aims will be accomplished. Aim 1: To examine the integrity of white matter pathways in high functioning autistic children. The hypothesis is that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits. Additionally, it is expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods. Aim 2: To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism. The hypothesis is that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities. Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors, and may be relevant to understanding the mechanisms underlying motor deficits in this disorder. ;
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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