Autistic Disorder Clinical Trial
Official title:
Improving the Understanding of Catatonia in Autism
Catatonia is a neuropsychiatric syndrome which is frequently missed or misdiagnosed among psychiatric patients. The current project is a systematic examination of catatonia which will characterize the phenotype and identify biological correlates that play a central role in the pathophysiology and effective pharmacological treatment of this condition.
The specific aims of the study are to:
1. Identify and phenotype participants ranging in age from 10-30 years old who are already
diagnosed with catatonia.
2. Review laboratory investigations already complete and further conduct any laboratory
tests which were not previously completed, to exclude a general medical etiology of
catatonia.
3. Obtain skin biopsy for fibroblast from participant to reprogram somatic cells to iPSC
(induced pluripotent cell lines) which will be differentiated to cortical neurons for in
vitro pharmacological studies against the target tissue.
Up to 30 patients will be consented. Eligibility will be determined through UM medical record
screening. When a potential participant is identified, the study team will reach out to the
treating clinician to make contact with participant about research interest. Informed consent
will be obtained prior to initiation of any study-related procedures. Consent may be emailed
at request of potential participants or their representative in advance of a scheduled
research appointment for their review. Additionally, informed consent will take place in
person both verbally and in writing, with adequate time for participants to ask questions.
Following informed consent, a comprehensive psychiatric interview will be completed to
identify overall psychiatric diagnoses and symptoms of catatonia. Based on this evaluation, a
decision will be made whether or not the individual is testable or untestable for
neurocognitive assessments.
A physical exam will be performed which will include weight, height, waist and head
circumference, as well as vital signs that include blood pressure and pulse rate.
Electronic medical record (EMR) will be reviewed to identify any comorbid medical condition,
lab results and medications received including the response to each agent. The medical
disorders (current or past) may include infective 26 27,28, metabolic/ endocrine 29,
autoimmune 30, toxic/ drug related 31 and seizure disorders.
Neuropsychological testing (NP): Standardized, well-validated tests will be used to assess
emotional, behavioral and neuropsychological functioning where possible. Clinician completed
ratings of autism symptoms will be completed, as well as parental rating scales for autism,
general behavioral issues, and quality of life. In addition, each participant will undergo
brief face-to face evaluations when catatonic symptoms do not preclude testing covering the
domains of intellectual functioning, academic achievement, receptive language, executive
functioning, and motor skills. These domains are typically included in neuropsychological
testing protocols, are brief, and place minimal demands on participants.
Laboratory tests: Laboratory work up required for the purpose of this study will include CBC,
CMP, free T4, TSH, thyroid antibodies, ANA, ASO, CRP, urine toxicology, urine or serum
organic acids, Cu and ceruloplasmin, anti-NMDAR receptor antibodies, CMA (chromosomal
microarray), fragile X, and EEG. If labs have been performed and are in the participant's
medical record, they may be used as part of this study and not re-requested based upon
physician judgment.
DNA: one 8ml vial of blood will be drawn and stored for future DNA analysis. DNA will be
stored as part of the Heinz C. Prechter Genetics Repository.
Skin biopsy: a skin biopsy will be obtained from a subset of participants who meet inclusion
and exclusion criteria.
Assessment: Standardized interviews and questionnaires will be completed by the participant
or their representative.
Reliability: will be established between the interviewers, at the level of the interview and
by best estimate diagnosis. All available sources of clinical information, including medical
records, informant data, the ADOS and the ADI-R, will be independently reviewed by a
non-interviewing psychiatrist or psychologist. Reviewers' "best-estimate" diagnoses will be
established at regular investigator meetings. If all are in agreement, the consensus
diagnosis is confirmed.
Quality Assurance: The PI and co-investigators will review all interviews to check for
completeness and accuracy. Interviewers will be given feedback and subjects will be
re-contacted as needed to correct problems or complete questions. This will reduce errors and
missing data.
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