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NCT01770548 Clinical Trial

Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism

Autism Clinical Trial

— NMDA-Autism  

Official title:
Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01770548
Other study ID # AORT08-FBB/NMDA-Autism
Secondary ID 2008-A01162-53
Status Completed
Phase N/A
First received January 15, 2013
Last updated January 13, 2017
Start date January 2009
Est. completion date June 2014

Study information
Verified date January 2017
Source University Hospital, Tours
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism

Description:

Analysis about 50 genes in glutamate synapse

Recruitment information / eligibility
Status Completed
Enrollment 497
Est. completion date June 2014
Est. primary completion date January 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 2 Years and older
Eligibility Inclusion Criteria:

- have a Pervasive Developmental Disorder

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
• DNA collection
DNA collection
Other:
• Auditory evoked potentials
auditory evoked potentials

Locations
Country Name City State
France CHRU - Centre de Ressources Autisme (CRA) Brest
France CHS du ROUVRAY Rouen
France Chru - Cic Tours
France CHRU - Pédopsychiatrie Tours

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Tours

Country where clinical trial is conducted

France, 

References & Publications (1)

Bonnet-Brilhault F, Alirol S, Blanc R, Bazaud S, Marouillat S, Thépault RA, Andres CR, Lemonnier É, Barthélémy C, Raynaud M, Toutain A, Gomot M, Laumonnier F. GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explor — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients two years
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