Atrophy, Muscular Clinical Trial
Official title:
Investigating the Effect of Neuromuscular Electrical Stimulation and Blood Flow Restriction Training on Physiological Deconditioning During Unloading and Retraining
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown.
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown. This study will examine the effectiveness and feasibility of a neuromuscular electrical stimulation and blood flow restriction protocol during a 7 day period of immobilisation. Multiple measures across several physiological systems will be obtained. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05670080 -
Does MI Have a Therapeutic Role in Arthroscopic Rotator Cuff Repair?
|
N/A | |
Recruiting |
NCT04436523 -
Blood Flow Restriction After Meniscus Repair
|
N/A | |
Completed |
NCT00964340 -
A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days
|
Phase 1 | |
Not yet recruiting |
NCT04861857 -
Effects of Parmigiano Reggiano on Muscle and Inflammatory Response to Eccentric Resistance Training in Older Adults
|
N/A | |
Recruiting |
NCT05776862 -
Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)
|
Phase 2 | |
Withdrawn |
NCT01039909 -
A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers
|
Phase 1 | |
Completed |
NCT05773469 -
Energy Balance in Extreme Environments: Finding the EI Limit
|
||
Withdrawn |
NCT06032247 -
Bilateral Versus Unilateral Strength Training After ACLR
|
N/A | |
Recruiting |
NCT05008705 -
Protein Intake Plus Neuromuscular Electrical Stimulation on Muscle Mass in Hospitalized Elderly
|
N/A | |
Not yet recruiting |
NCT05760066 -
Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults
|
N/A | |
Completed |
NCT01476072 -
31P MRS Ischaemic Exercise Optimisation and COPD
|
Phase 1 |