Comparison Of Outcome Of Microneedling With Autologous PRP Vs Microneedling With Topical Insulin In Treatment Of Post Acne Atrophic Scars.

ATROPHIC ACNE SCARS Clinical Trial

Official title:

Comparison Of The Outcome Of Treatment of Microneedling With Autologous Platelet- Rich -Plasma Versus Microneedling With Topical Insulin In The Treatment Of Post Acne Atrophic Scars.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06002854
• Other study ID #: NO.F.2-81/2022-GENL/252/JPMC
• Status: Completed
• Phase: Phase 2
• Start date: August 1, 2022
• Est. completion date: February 1, 2023

Study information

• Verified date: June 2023
• Source: Jinnah Postgraduate Medical Centre
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Microneedling with topical INSULIN is a simple, effective tool for building body's new collagen layers and thus an alternative to all erosive techniques such as lasers, peels. The skin responds to fine punctures with the release of growth factors. 8 It is a safe procedure that can be performed in the office without complications, with a good cost-benefit because it is economically viable without any effect on patient's daily activities. 9

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: February 1, 2023
• Est. primary completion date: December 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

• postacne atrophic scars = 2 on Goodman and Baron's acne scar-grading system

• Either gender.

• Age 20-50 years.

Exclusion Criteria:

• lactation and pregnancy

• skin cancers and infection

• photosensitivity like SLE ,XP

• use of RETINOIDS in last 6 months.

Related Conditions & MeSH terms

• ATROPHIC ACNE SCARS
• Atrophy

Intervention

Drug:
• PRP( platelet rich plasma) and Insulin human
Microneedling with autologus PRP reduces inflammationin acne scars. Insulin human is a new topical drug which is used nowadays for acne scars as it is more effective in producing collagen formation as well as new blood vessel formation

Locations

Country	Name	City	State
Pakistan	JPMC	Karachi	Sindh

Sponsors (1)

Lead Sponsor	Collaborator
Jinnah Postgraduate Medical Centre

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Efficacy of Topical Insulin R with microneedling versus Platelets rich plasma in atrophic acne scars	Efficacy will be assessed by using Goodman and Baron Qualitative Scar Grading System	Efficacy will be assesed upto 4 months.