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NCT00902096 Clinical Trial

Predictors of Cord Blood Immunoglobin E (IgE) Levels

Atopy Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00902096
Other study ID # 2009008
Secondary ID
Status Recruiting
Phase N/A
First received May 13, 2009
Last updated May 13, 2009
Start date April 2009

Study information
Verified date May 2009
Source Min-Sheng General Hospital
Contact Chien-Han Chen, MD
Phone 886-3-3179599
Email chinsword@yahoo.com.tw
Is FDA regulated No
Health authority Taiwan: Institutional Review Board
Study type Observational

Clinical Trial Summary

Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.

Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.

Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.

Recruitment information / eligibility
Status Recruiting
Enrollment 800
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- Mothers in pregnancy 18 years of age or older, AND

- Mothers able to speak Chinese.

Exclusion Criteria:

- Infant delivered at less than 36 weeks' gestation,

- Infant with Apgar score in 5 minutes after birth < 7,

- Infant with a major congenital anomaly, OR

- Infant admitted to an intensive care unit.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan Min-Sheng General Hospital Taoyuan

Sponsors (1)
Lead Sponsor Collaborator
Min-Sheng General Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome
Type Measure Description Time frame Safety issue
Primary cord blood IgE at birth No
Secondary Cord blood cytokines or other mediators at birth No
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