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Real-world Experience on the Use of Upadacitinib in the Treatment of Moderate-severe Adult Atopic Dermatitis (ERUDA) — ERUDA  

Atopic Dermatitis Clinical Trial

Official title:
Esperienza Real-world Sull'Uso di Upadacitinib Nel Trattamento Della Dermatite Atopica Moderata-severa Dell'Adulto

Clinical Trial Summary

Real-world experience on the use of Upadacitinib in the treatment of Adult moderate-severe atopic dermatitis

Clinical Trial Description

Atopic dermatitis (DA) is a chronic-recurrent inflammatory skin disease with high prevalence in children. Clinical remission is frequently observed during or after childhood although it may persist and/or recur, even after long and transient remission, in adulthood. In addition, in some patients the DA begins in adulthood: in these cases, we speak of DA adult-onset. In addition to the diagnostic framework, it is also important in clinical practice to assess the severity of the disease on which the choice of treatment is based, which will also take into account other factors such as: possible comorbidities, Previously performed therapies and patient needs. For the management of moderate-severe forms of atopic dermatitis topical drugs, phototherapy, traditional immunomodulating drugs and a biological drug are currently available. Compared to other chronic inflammatory skin diseases the therapeutic paraphernalia should be considered limited, with most systemic drugs that have no indication for the treatment of DA (off-label use). In the pipeline there are numerous drugs that have reached an advanced stage of development. These include upadacitinib, a new-generation oral drug (small molecule) that selectively inhibits the signal mediated by Janus kinases 1 (JAK-1), has recently received approval for treatment of DA by EMA and AIFA to begin compassionate use of patients deemed contraindicated, intolerant, and/or non-responsive to traditional systemic therapies and biological therapy. - Evaluation of the effectiveness of upadacitinib using the EASI score Secondary objectives - Evaluation of the safety profile of upadacitinib - Predictive factors of treatment response - Assessment of patient quality of life ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05989932
Study type Observational [Patient Registry]
Source Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse
Contact Ketty MD Peris
Phone 0630154211
Email ketty.peris@unicatt.it
Status Recruiting
Phase
Start date November 19, 2021
Completion date November 19, 2031
View Details
See also
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