Atopic Dermatitis Clinical Trial
Official title:
Skin Testing With Recombinant Bet v 1 and Hypoallergenic Recombinant Bet v 1 Fragments to Dissect the Contribution of IgE to Chronic Allergic Skin Inflammation
Aim of this study is to use the major allergen 1 of birch-tree pollen (Bet v 1, Betula verrucosa, synonymous Betula pendula), to investigate the contribution of immunoglobulin E (IgE)- versus non-IgE-mediated mechanisms to chronic skin inflammation in atopic dermatitis patients.
In this study non-IgE-reactive recombinant Bet v 1 (rBet v 1) fragments (F1: aa 1-74; F2: aa
75-160) and the fully IgE-reactive recombinant Bet v 1 (aa 1-160)will be used for skin prick
testing and atopy patch testing in birch pollen allergic patients with birch pollen induced
exacerbation of atopic dermatitis. For control purposes birch pollen allergic patients
without birch pollen-induced atopic eczema, persons with allergies other than to birch and
non-allergic people will be tested.
The individuals will be subjected to in vivo skin prick and atopy patch testing with rBet v
1, rBet v 1 fragment 1, rBet v 1 fragment 2 and an equimolar mix of the rBet v 1 fragments.
In parallel, the IgE reactivity, and in vitro T cell proliferation, and cytokine production
will be studied. Those analyses should help to determine the relevance of IgE mediated
mechanisms to chronic skin inflammation and T cell proliferation in AD patients.
A staining for the surface markers chemokine receptor (CCR4)+ and cutaneous lymphocyte
antigen (CLA)+ which reportedly are enriched in inflamed skin will further allow to
investigate whether patients with high numbers of T lymphocytes expressing CCR4 and CLA tend
to exhibit stronger skin inflammation. Moreover, allergen-specific antibody and T cell
responses will be analyzed 6-8 weeks after the epicutaneous allergen application.
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Observational Model: Case-Only, Time Perspective: Prospective
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