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Clinical Importance of Filaggrin Gene Mutation for Treatment Outcome in Atopic Dermatitis

Atopic Dermatitis Clinical Trial

Official title:
Do Mutations in the Filaggrin Gene Have Clinical Importance for the Treatment Outcome in Atopic Dermatitis?

Clinical Trial Summary

Atopic dermatitis is a common disease which affects about one million people in Finland at some stage of their life. In atopic dermatitis we see a superficial inflammation of the skin and a defect in skin barrier function. The filaggrin protein plays a central role in the skin barrier function and studies indicate that about 30% of patients with atopic dermatitis have a mutation in the filaggrin gene. The aim of the study is to investigate whether a mutation in the filaggrin gene affects the clinical treatment outcome in patients with atopic dermatitis. If a mutation predisposes to a worse response to treatment, this could be examined and those patients with the mutation could be given extra treatment support for their atopic dermatitis. The prevalence of filaggrin mutation in the Finnish non-atopic population is studied in the control group.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01689805
Study type Observational
Source Helsinki University Central Hospital
Contact Anita Remitz, MD, PhD
Phone +358-9-4711
Email anita.remitz@hus.fi
Status Recruiting
Phase N/A
Start date June 2011
View Details
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