Atopic Dermatitis Clinical Trial
Official title:
The Effects of Emollient Therapy on the Skin Barrier Function
The goal of this study is to better understand what effect emollients (moisturizers) have on
the skin in young children and adults.
Subjects will be recruited from PI and Sub-I clinics and Oregon Health & Science University
(OHSU) research opportunities website.
1. Adult and Adolescent Study:
Moisturizer Intervention - There will be 2-3 visits for this study: a screening visit, a
baseline visit, and a final visit. Adults with a history of eczema will be asked to
apply one of four possible moisturizers to one arm and nothing to the other arm for four
weeks. The moisturizers, which will be assigned to the subjects, include either Cetaphil
Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe Moisturizing Cream, or Vaseline
100% Petroleum Jelly. Subjects can use other skin treatments as needed for their skin
condition, but may not treat the arms during the study. Non-invasive tests of the skin
will be made at Visit 1 and after four weeks (Visit 2). The skin measurements that will
be performed are:
- Transepidermal loss (TEWL)- measures how much water is lost across the skin barrier
- Skin Cohesion and TEWL - TEWL after 5, 10, 15, and 20 tape strips will measure skin
barrier function after tape-stripping
- Skin electrical capacitance - measures the moisture in the top layer of skin
- Skin pH - measures the acidity of the skin
- Stratum corneum cohesion assay - tape-stripping to measure the protein removed from
the top layer of skin
- Lipidomic analysis - measures the lipids, or oils, in the top layer of skin Control
- There will be 1-2 visits for this group: a screening visit and baseline visit,
which can be combined. Non-invasive tests of the skin will be taken and include the
skin measurements that will be performed are the same as the Moisturizer
Intervention group.
2. Pediatric Study: There will be 2-3 visits for this study: a screening visit, a baseline
visit, and a final visit. Infants and toddlers between 3 months and 3 years of age
without a history of skin barrier diseases will be assigned to a moisturizer, which
include either Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe
Moisturizing Cream, or Aveeno Skin Relief Moisture Repair Cream. Non-invasive tests of
the skin will be made at Visit 1 and after four weeks (Visit 2).
- TEWL- measures how much water is lost across the skin barrier
- Skin electrical capacitance - measures the moisture in the top layer of skin
- Skin pH - measures the acidity of the skin
n/a
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