Atopic Dermatitis Clinical Trial
Official title:
Immunotherapy of Atopic Dermatitis in Adult Patients by Anti-measles Vaccination IDA (Immunothérapie de la Dermatite Atopique)Protocol
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. AD is very frequent,
and involves T lymphocytes cells. Measles vaccination, as well as measles vaccine, induces a
temporary immunosuppression; furthermore, an improvement of AD has been observed during
measles infection.
This trial is aimed at demonstrating that measles vaccine is able to create an
immunomodulation and to improve AD symptoms.
30 adult patients of both sexes with moderate to severe AD will be randomly assigned to
measles vaccine (ROUVAX ®), or placebo (vehicle) and follow-up for 45 days.
The primary outcome is the effect of anti-measles vaccination on the T cell responses in
patients; Other outcomes include: clinical evolution of AD, as measured by the SCORAD, the
evolution of blood level of measles specific IgE and antibodies; evolution of other
biomarkers and phenotypic characteristics of T lymphocytes.
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. AD is very frequent,
and involves T lymphocytes cells. Measles vaccination, as well as measles vaccine, induces a
temporary immunosuppression; furthermore, an improvement of AD has been observed during
measles infection.
This trial is aimed at demonstrating that measles vaccine is able to create an
immunomodulation and to improve AD symptoms.
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