Atopic Dermatitis Clinical Trial
Official title:
Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis
The purpose of this research study is to better understand adherence to Locoid when people use it to treat atopic dermatitis.
An investigator-blinded prospective study of subjects with mild to moderate atopic dermatitis
(>5% Body Surface area and 2 or 3 on the Investigator Global Assessment (IGA) scale). The
drug will be used within FDA-approved labeling. Subjects will be randomized to each of the
following topical hydrocortisone 17-butyrate 0.1% preparations— ointment, cream or lipocream—
in the manufacturer's original tube fitted with a Medication Event Monitoring System (MEMS)
cap. This cap records dates and times the assembly is opened and this data can be downloaded
and tabulated with the associated software.
The study will consist of a 2-week Treatment Phase (visits at Baseline and Week 2). Subjects
will be instructed to apply the medication twice daily (morning and evening) for 2 weeks to
all of their AD lesions.
Adherence will be measured by MEMs cap.
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