Atopic Dermatitis Clinical Trial
Official title:
Genetics of Atopic Dermatitis - Eczema Herpeticum
People with atopic dermatitis (AD), or eczema, are susceptible to skin infections and inflammations. Some individuals with AD develop a condition known as eczema herpeticum (EH) following exposure to the herpes simplex virus (HSV). The purpose of this study is to identify the genetic determinants that lead people with AD to develop EH and similar conditions caused by other viruses.
AD is a chronic inflammatory skin disorder characterized by recurrent viral skin infections.
However, people with AD do not all develop the same infections. For example, some people
with AD who receive the smallpox vaccine develop a life-threatening condition known as
eczema vaccinatum (EV). This study focuses on individuals with AD who also have a history of
eczema herpeticum (ADEH+), a condition similar to EV. It is unlikely that the differences in
the development of skin infections are due to differences in viral exposure, and instead due
to differences in each individual's response to viruses. The purpose of this study is to
determine the genetic pathways which are responsible for the development of viral skin
infections in people with AD.
Participants in this study will also be enrolled in the ADVN Biomarker Registry Study. There
will be only one clinical visit for this study at which blood and/or skin samples may be
collected. The samples will then have high-throughput genotyping to define genetic markers
in individuals susceptible to viral infections.
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Time Perspective: Cross-Sectional
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