Double Anaerobic Threshold in Athletes

Athlete Clinical Trial

Official title:

Evaluation of the Presence of a Double Anaerobic Threshold in a Population of Athletes

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05770453
• Other study ID #: CCM 1719
• Status: Recruiting
• Start date: March 15, 2022
• Est. completion date: December 2023

Study information

• Verified date: February 2023
• Source: Centro Cardiologico Monzino
• Contact: Piergiuseppe Agostoni, Prof
• Phone: +39 0258002772
• Email: piergiuseppe.agostoni[@]cardiologicomonzino.it
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

During an incremental cardiopulmonary exercise test (CPET) performed with a ramp protocol, it is very important to determine the anaerobic threshold, defined as the point at which the metabolism switches from being predominantly aerobic to also being anaerobic. The anaerobic threshold can be determined invasively, by identifying the increase in blood lactates with an arterial sampling, or, more commonly, non-invasively by three methods: the V-slope method, the ventilatory equivalents method and by using end-expiratory oxygen and carbon dioxide pressure (PETO2 and PETCO2 respectively). Normally, the anaerobic threshold is determined by the first method and the other two are used to confirm the value. The finding of different anaerobic threshold values using these three methods has been reported anecdotally in the past, while a prevalence of 11% in a healthy population has recently been described. Regular training, particularly that aimed at endurance sports, is able to shift the anaerobic threshold to higher exercise intensities. At present, the physiological reasons for the presence of a double threshold are unclear.

The aim of the study is to identify the anaerobic threshold by means of the V-slope method and by means of the ventilatory equivalents method in athletes who have performed an incremental ramp CPET at the laboratories of the investigating centres, to assess in how many athletes a double threshold is present and to try to interpret the physiological/ pathophysiological significance of this finding.

In this retrospective and prospective observational study, healthy male and female athletes who have had a cardiopulmonary test at our laboratories from 2007 to the present (retrospectively recruited) and prospectively recruited until the calculated sample size is reached will be enrolled.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 2023
• Est. primary completion date: December 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• no major present or past illnesses, no ongoing treatment

• At least 2 training sessions per week.

Exclusion Criteria:

• Current illnesses and treatments for any physical condition that could potentially alter performance

• Subjects who have performed a submaximal test (RER < 1.05)

• CPET during which the AT determination is poorly assessable, i.e. due to changes in respiration.

• obese subjects (BMI >30)

Related Conditions & MeSH terms

• Anaerobic Threshold
• Athlete
• Cardiopulmonary Exercise Test

Locations

Country	Name	City	State
Italy	Azienda Ospedaliero-Universitaria Careggi	Florence
Italy	University of Foggia	Foggia
Italy	Centro Cardiologico Monzino	Milan

Sponsors (3)

Lead Sponsor	Collaborator
Centro Cardiologico Monzino	Azienda Ospedaliero-Universitaria Careggi, University of Foggia

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Athletes groups	Identification of two groups of athletes (those with identified double anaerobic threshold and those without)	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Groups differences in age	Assess whether there are differences in age (years) between the two groups of subjects.	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Groups differences in sport practised	Assess whether the two groups of subjects differ in term of the sport practised (information collected during patient interview)	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Groups differences in exercise performance	Assess whether the two groups of subjects differ in term of exercise performance (peak power (Watts) reached during CPET)	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Groups differences in VO2	Assess whether there are differences in the oxygen intake VO2 (cardiopulmonary exercise test) between the two groups	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Groups differences in VE/VCO2 slope	Assess whether there are differences in minute ventilation/carbon dioxide production relationship VE/VCO2 slope (cardiopulmonary exercise test) between the two groups	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Groups differences in VE	Assess whether there are differences in minute ventilation VE (cardiopulmonary exercise test) between the two groups	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Differences in VO2 at the two thresholds	Highlight the differences in oxygen intake VO2 (cardiopulmonary exercise test), in the subjects with double anaerobic threshold, at the two thresholds.	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Differences in VE/VCO2 at the two thresholds	Highlight the differences in minute ventilation/carbon dioxide production relationship VE/VCO2 slope (cardiopulmonary exercise test), in the subjects with double anaerobic threshold, at the two thresholds.	immediately after the incremental cardiopulmonary exercise test evaluation
Secondary	Differences in VE at the two thresholds	Highlight the differences in minute ventilation VE (cardiopulmonary exercise test), in the subjects with double anaerobic threshold, at the two thresholds.	immediately after the incremental cardiopulmonary exercise test evaluation