Asymptomatic Narrow Angles Clinical Trial
Official title:
Prophylactic Laser Iridotomy for Eyes With Narrow Drainage Angles; A Randomised Controlled Trial
This is a multicentric, randomised, controlled study comparing Laser Iridotomy (LI) to no treatment in subjects with asymptomatic narrow angles (ANA).One eye of each subject with ANA will be randomised to undergo LI and the other eye will be left alone and will serve as an internal control. Subjects are proposed to be followed up once a year for 5 years.
Objective: This study will compare LI versus no treatment in subjects with asymptomatic
narrow angles, the anatomical trait that predisposes to primary angle closure glaucoma
(PACG), in order to assess the effectiveness of prophylactic treatment in the prevention of
blindness due to PACG.
Eligibility: 1. Bilateral Narrow angles; 2. Age 50 years and above; 3. Informed consent
obtained prior to or at baseline visit.
Trial Design: Subjects with asymptomatic ANA undergoes randomisation after comprehensive
ocular exam followed by randomisation to LI in one eye and no treatment in the other eye.
Follow up is done for 5 years with yearly examination.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention