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TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma

Astrocytoma Clinical Trial

Official title:
A Phase 2 Investigator Initiated Study to Determine the Efficacy and Safety of TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma

Clinical Trial Summary

Randomized phase 2 study TVB-2640 in combination with Bevacizumab versus Bevacizumab alone.

Clinical Trial Description

Eligible patients will be randomized into 2 separate arms: - Arm number one will receive Bevacizumab every 2 weeks in combination with TVB-2640 from day 1 until day 28 of the first cycle. - Arm number two will receive Bevacizumab alone every 2 weeks, from on days 1 and 15 of the first until day 28 of the first cycle. - MR-Spectroscopy will be obtained on all patients (both arms) at day 28 of first cycle. - Starting on cycle 2 day 1, all patients will converge to a single arm and will continue to receive bevacizumab every 2 weeks in combination with TVB-2640. Every cycle will last 28 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03032484
Study type Interventional
Source The University of Texas Health Science Center at San Antonio
Contact
Status Completed
Phase Phase 2
Start date May 18, 2017
Completion date April 5, 2021
View Details
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