Astrocytoma Clinical Trial
Official title:
Molecular Correlates and Clinical Significance of Positron Emission Tomography With FET-PET in Combination With Perfusion-weighted Magnetic Resonance Imaging (PWI) in Patients With Low Grade Gliomas
The aim of the study is to compare the two imaging modalities perfusion weighted MR-imaging and FET-PET in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within a homogeneously appearing tumor. Additionally, therapeutic effects should be assessed during a time period of two years.
Status | Active, not recruiting |
Enrollment | 38 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - neuroradiologically suspected low grade glioma (Astrocytoma WHOI-II, Oligodendroglioma WHO II, Oligoastrocytoma WHO II) - histological verification will be obtained either by microsurgery or by stereotactic biopsy - patients older than 18 years - Karnofsky Performance Score >=70 - pregnant or nursing female patients will not be included in this study Exclusion Criteria: - patients in whom informed consent cannot be obtained due to organic brain syndrome or insufficient language skills - patients who cannot lie quiet for a time period of app. two hours during the FET-PEt scan - medical history of a metastatic brain disease - patients in whom an MRI scan cannot be performed due to claustrophobia metallic protheses or pacemakers etc. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Germany | University Hospital, Duesseldorf | Duesseldorf | North Rhine-Westphalia |
Germany | University Hospital Munich, Department of Neurosurgery | Munich | Bavaria |
Lead Sponsor | Collaborator |
---|---|
Ludwig-Maximilians - University of Munich | Deutsche Krebshilfe e.V., Bonn (Germany) |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overall survival | 24 months | No | |
Secondary | Progression Free survival | 24 months | No |
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