Use of Air Purifiers to Improve Respiratory Health in Children

Asthma in Children Clinical Trial

Official title:

Use of Air Purification Devices in the Homes of Children and Young People to Improve Respiratory Health - a Pilot Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05817357
• Other study ID #: UoL001754
• Status: Active, not recruiting
• Phase: N/A
• Start date: May 2, 2023
• Est. completion date: July 30, 2024

Study information

• Verified date: June 2023
• Source: University of Liverpool
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes.

The main questions it aims to answer are:

• Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes

• Is the use of an air purifier in the home acceptable to children and young people and their families?

Children and young people with asthma attending our clinic will be selected at random to be invited to take part. For those that take part, an air purifier (Rensair Ltd. - Rensair Compact) will be installed in their home for a one-year period. Data will be collected on numbers of asthma attacks, rescue oral steroids, quality of life, symptoms, lung function at the beginning and at three-monthly intervals throughout the study period. The acceptability to children and young people and their families taking part in this study of using an air purifier in their home will also be assessed.

Description:

The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes.

The main questions it aims to answer are:

• Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes (including reduction in asthma exacerbations, improvement in symptom control, improvement in quality of life).

• Is the use of an air purifier in the home acceptable to children and young people and their families?

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 20
• Est. completion date: July 30, 2024
• Est. primary completion date: July 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 15 Years

Eligibility

Inclusion Criteria:

• Aged 5 to 15 years old

• Attend the asthma clinic in our hospital

• Have a confirmed physician-diagnosis of asthma from the asthma clinic

• Live in mainland England (this is due to delivery of the air purification units and also associated maintenance of them)

Exclusion Criteria:

• Nil specific other than not meeting inclusion criteria

Related Conditions & MeSH terms

• Asthma in Children

Intervention

Device:
• Rensair Compact air purifier unit
Installation of Rensair Compact air purifier (Rensair Ltd.) in the homes of children/young people participating in this study

Locations

Country	Name	City	State
United Kingdom	Alder Hey Children's Hospital	Liverpool	Merseyside

Sponsors (1)

Lead Sponsor	Collaborator
University of Liverpool

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of asthma exacerbations (asthma attacks)	Asthma attacks and unscheduled healthcare visits due to acute asthma (including ED attendance, admission, GP/primary care attendance) - assessed by questionnaire and hospital-recorded attendances/admissions	12 months
Primary	Number of rescue oral steroid courses	Number of rescue oral steroid courses - assessed by questionnaire and prescription data	12 months
Primary	Quality of life - mini paediatric asthma quality of life questionnaire score	Quality of life using mini paediatric asthma quality of life questionnaire - the higher the score the better the quality of life	12 months
Primary	Asthma control test score	Asthma control test (ACT) or child asthma control test score (cACT) - depending on age of participant - the higher the score the better the asthma control	12 months
Primary	Amount of asthma reliever medication use per week	Amount of use of asthma reliever medication use over a one week period (assessed as a categorical value)	12 months
Primary	Number of school days absent due to asthma	Number of school days missed due to asthma - assessed by questionnaire	12 months
Primary	Number of parent/carer work days missed due to their child's asthma	Number of work days missed due to child's asthma - assessed by questionnaire	12 months
Primary	Forced expired volume in one second (FEV1)	Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score	12 months
Primary	Forced vital capacity (FVC)	Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score	12 months
Primary	FEV1:FVC	Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score	12 months
Primary	Measurement of fraction of exhaled nitric oxide (FeNO)	Fraction of exhaled nitric oxide measurements	12 months
Primary	Acceptability to children and families participating of using an air purifier in their home	Acceptability to children and young people and their families taking part in the study in terms of use of air purifier in their homes - assessed by questionnaire	12 months