Assisted Reproductive Technology Clinical Trial
Official title:
Effect of Assisted Reproductive Technology on Cardiac Development in Childhood Assessed by Echocardiography
Assisted reproductive technology (ART) has extensively allowed pregnancy for infertile couples. However, the long-term effect of ART exposure on cardiovascular development and potential association with ART procedure and parental factors is confused. The aim is to shed more light on the pattern and extent of cardiovascular developmental alteration among ART children and its association with potential confounders.
A historic cohort study was designed with prospective follow-up of ART children conceived in
the Clinical Centre of Reproductive Medicine (CCRM) and born in Maternal-Fetal Medicine Unit
(MFMU) of First Affiliated Hospital of Nanjing Medical University (FAHNMU) from 1 January
2002 to 31 December 2012.
The present design is a prospective single-center study in FAHNMU. ART group will be
recruited by a non-random, consecutive sample on the basis of the unique personal
identification number assigned to ART children conceived in CCRM and born in MFMU.
The controls will be recruited by a non-random, consecutive sample on the basis of the
spontaneous conception population attending the MFMU of FAHNMU during the same period as ART
group for prenatal screening and subsequent delivery considering their age.
;
Observational Model: Case Control, Time Perspective: Prospective
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