Arthritis Clinical Trial
Official title:
Allograft Meniscal Arthroplasty for the Treatment of Basal Joint Arthritis of the Thumb
Hypothesis:
The use of knee meniscal allograft as a joint spacer and stabilizer is a viable option for
the surgical treatment of basal joint arthritis of the thumb.
A variety of surgical procedures have been developed for the treatment of basal joint
osteoarthritis of the thumb. Problems with persistent pain and poor function have been
reported to some degree for each of these procedures. Using the concept of an implant acting
as a spacer and stabilizer the investigators proposed and implemented a novel surgical
technique using allograft knee meniscus as a biologic implant for the treatment of basal
joint arthritis of the thumb.
Hypothesis:
The use of knee meniscal allograft as a joint spacer and stabilizer is a viable option for
the surgical treatment of basal joint arthritis of the thumb.
Introduction:
A variety of surgical procedures have been developed for the treatment of basal joint
osteoarthritis of the thumb. Problems with persistent pain and poor function have been
reported to some degree for each of these procedures. Promising results were originally
reported (2004) for the Artelon carpometacarpal (CMC) implant (Small Bone Innovations,
Morrisville, PA) procedure which utilized the concept of a spacer and stabilizer of the CMC
joint . Recent studies however, have demonstrated problems due to a foreign body reaction
with the Artelon implant requiring revision surgery. Using the concept of an implant acting
as a spacer and stabilizer we proposed and implemented the use of allograft knee meniscus as
a biologic implant in the treatment of basal joint arthritis of the thumb
Methods:
A prospective study was performed on four thumbs using an allograft knee meniscus
transplanted into the thumb CMC joint using the surgical technique described for that of the
Artelon implant (Small Bone Innovations, Morrisville, PA). Data collected included: pain
level, grip strength, tip, key and pinch strength, carpometacarpal, metacarpophalangeal,
interphalangeal, and oppositional range of motion, as well as Disabilities of the Arm,
Shoulder, and Hand (DASH) scores. Interval radiographic analysis is to be performed.
Endpoints for data collection will be at three months, six months, one, two, three, four,
and five years follow up.
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Observational Model: Cohort, Time Perspective: Prospective
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