Arthritis, Rheumatoid Clinical Trial
Official title:
Bone MicroArchitecture Abatacept in Rheumatoid Arthritis Patients (BMA2)
Rheumatoid Arthritis patients management reposes primarily on the use of disease-modifying
antirheumatic drugs (DMARDs).
Among DMARDs available in 2015, researchers demonstrated the ability to reduce synovitis,
biomarkers of inflammation, and bone destruction.
Given the demonstration of correlation between joint inflammation and structural progression
at each joint level as well as the opportunity for bone remodeling with resolution of joint
inflammation, researchers expect to observe an improvement in bone micro-architecture
parameters specifically in rheumatoid arthritis patients without remaining joint inflammation
3 months following abatacept treatment initiation.
Rheumatoid Arthritis patients management reposes primarily on the use of disease-modifying
anti-rheumatic drugs. In patients responding insufficiently to Methotrexate, and/or other
disease-modifying anti-rheumatic drugs (DMARD) strategies, with or without glucocorticoids,
biological DMARD (TNF inhibitors, abatacept or tocilizumab, and, under certain circumstances,
rituximab) should be commenced with Methotrexate. Among DMARD available in 2015, abatacept
has demonstrated the ability to reduce synovitis, biomarkers of inflammation, and bone
destruction. Monitoring rheumatoid arthritis patients after starting abatacept by US exams
observed a strong reduction of power Doppler ultra-sonography at 3 months in two third of
patients.
Given the demonstration of correlation between joint inflammation and structural progression
at each joint level as well as the opportunity for bone remodeling with resolution of joint
inflammation, researchers expect to observe an improvement in bone micro-architecture
parameters specifically in rheumatoid arthritis patients without remaining joint inflammation
3 months following abatacept initiation.
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