Arthritis, Rheumatoid Clinical Trial
Official title:
A Randomised, Double-blind, Placebo-controlled, Parallel Group Study to Investigate the Anti-inflammatory and Metabolic Effects of Rosiglitazone XR, 8mg Once Daily, in Subjects With Rheumatoid Arthritis
Verified date | October 2016 |
Source | GlaxoSmithKline |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To assess whether the anti-inflammatory effects of rosiglitazone result in improvements in Rheumatoid Arthritis symptoms in patients for whom their existing Disease Modifying Anti-Rheumatic Drug (DMARD) treatment does not give adequate relief.
Status | Completed |
Enrollment | 96 |
Est. completion date | December 2006 |
Est. primary completion date | December 2006 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Rheumatoid Arthritis insufficiently controlled by existing disease-modifying anti-rheumatic drugs - Subjects will have at least 6 swollen joints plus 2 of the following: 6 tender joints (of 28 joints); early morning stiffness lasting more than 30 minutes; ESR greater or equal to 28mm/h - must be receiving a stable dose of disease-modifying anti-rheumatic therapy for at least 2 months prior to participating in the study. Exclusion criteria: - Women who are lactating, pregnant, or planning to become pregnant during the course of the study including 30 days following conclusion of study medication - Systolic blood pressure (SBP) >165 mmHg or diastolic blood pressure (DBP) >95 mmHg while receiving optimal antihypertensive therapy - Any clinically significant abnormality identified on the screening physical exam, laboratory tests, or ECG, which in the judgement of the Investigator makes the subject unsuitable for inclusion in the study - a history of alcohol abuse within the past 3 years or consumes >3 units per day for males and >2 units per day for females or has a history of cirrhosis or stigmata of chronic liver disease - a history of liver disease or has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels >2.5 times upper limit of normal and total bilirubin levels greater than 1.5 times the upper limit of normal (unless associated with predominantly indirect bilirubin or Gilbert's syndrome) at screening - using glucocorticoid at doses >10 mg/day currently or within the last 3 months or may be expected to do so during the course of the study - The subject's dose of NSAIDs, COX-2 inhibitors or glucocorticoids has changed at any time during the past 2 weeks prior to screening or may be expected to change during the course of the study - The subject's dose or treatment with a statin has changed at any time during the past 3 months prior to screening or may be expected to change during the course of the study - a history of renal disease or has serum creatinine = 132mol/L for males and =130mol for females - has diabetes mellitus that requires medication or hyperglycaemia with a HbA1c of >7% - History of new cardiovascular event within the last 6 months (i.e., intervention, percutaneous coronary intervention, vascular surgery, acute coronary syndrome [non Q-wave myocardial infarction, Q-wave myocardial infarction, unstable angina) or significant arrhythmia; or major intervention (e.g., cardiac surgery or angiography plus stenting) scheduled - Concurrent or past medical history of congestive heart failure or pulmonary oedema - A presence of severe peripheral oedema or a medically serious fluid-related event - has significant cardiac, pulmonary, metabolic, renal, hepatic, gastrointestinal or immunological conditions that, in the opinion of the Investigator and/or GSK medical monitor, places the subject at an unacceptable risk as a participant in this trial - a history of malignancy in the last 5 years, except for surgically cured basal cell carcinoma (>2 years prior to first dosing) - a history of HIV, or chronic hepatitis B or positive C serology - a history of drug abuse - has participated in a clinical trial within the 3 months before the start of the study for non-biological therapy; or within 6 months of a biological therapy - on a biological therapy or has received biological therapy within 6 months prior to screening - has donated blood in excess of 500 mL within 56 days prior to dosing - The subject is at risk of non-compliance in following directions or adhering to study restrictions - a history of drug or other allergy, which, in the opinion of the physician responsible, contraindicates their participation - has anaemia defined by haemoglobin concentration <11 g/dL for males or <10 g/dL for females |
Country | Name | City | State |
---|---|---|---|
Lithuania | GSK Investigational Site | Kaunas | |
Lithuania | GSK Investigational Site | Vilnius | |
United Kingdom | GSK Investigational Site | Glasgow | Lanarkshire |
United Kingdom | GSK Investigational Site | Glasgow | Lanarkshire |
United Kingdom | GSK Investigational Site | Glasgow | Lanarkshire |
Lead Sponsor | Collaborator |
---|---|
GlaxoSmithKline |
Lithuania, United Kingdom,
This study has not been published in the scientific literature.
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Disease Activity Score (DAS) following 6 months of treatment | 6 Months | ||
Secondary | Disease activity at 3 months and 6 months, e.g., number of affected joints Patient Assessments of Improvements in Disease Activity, e.g., fatigue and pain assessment Assessment of safety, tolerability and biological activity | Disease activity at 3 months and 6 months |
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