Arteriovenous Malformations Clinical Trial
Official title:
Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations
Brain arteriovenous malformations are abnormal communications between brain arteries and veins with an intervening tangle of abnormal arteries (nidus). Brain AVMs may be asymptomatic or symptomatic, presenting with acute hemorrhage or neurological symptoms. Brain AVMs that have not bled carry a yearly risk of intracranial hemorrhage of approximately 4% (Ondra et al.). The management is multidisciplinary involving neurosurgeons, interventional neuroradiologists, radiation physicians, neurologists and allied health care personnel. Patients may be treated with open neurosurgery, endovascular embolization, radiation therapy or any combination of these treatments. The goal of the treatment is to eliminate the brain AVM while preserving normal flow to the surrounding normal arteries. This involves obliteration of the shunting of blood via the AVM arteries to veins by a variety of treatments. The treatment regimen is individualized dependent on natural history, the angioarchitecture, location, risk of treatment(s) and patient wishes.
Status | Recruiting |
Enrollment | 12 |
Est. completion date | March 2024 |
Est. primary completion date | March 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: 1. Informed consent 2. Brain AVMs previously diagnosed with either CT Angiography, MRI or catheter angiography. 3. Undergoing cerebral catheter angiography for clinical evaluation of the brain AVM. Patients with brain AVMs scheduled for catheter cerebral angiography will undergo MRI (GE 3T) within 3 months. 4. Age > 18 years. 5. mRS <=2 6. Brain AVM visible on MRI, i.e. nidus > 1 cm Exclusion Criteria: 1. Contraindication to MRI eg. Non-MRI compatible implant, severe claustrophobia 2. Contraindication for contrast: GFR < 60 ml/min, allergy to contrast |
Country | Name | City | State |
---|---|---|---|
Canada | The Ottawa Hospital | Ottawa | Ontario |
Lead Sponsor | Collaborator |
---|---|
Ottawa Hospital Research Institute |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | SWAN and TRMRA with catheter angiography will be measured to determine if accuracy of brain MRI for follow-up of treated brain AVM can be improved | 24 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03306823 -
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1
|
N/A | |
Recruiting |
NCT03306836 -
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2
|
N/A | |
Completed |
NCT01347307 -
Stereotactic Body Radiotherapy for Spine Tumors
|
N/A | |
Recruiting |
NCT02042326 -
Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations
|
Phase 2 | |
Recruiting |
NCT05484245 -
Sonography-guided Resection of Brain Mass Lesions
|
N/A | |
Recruiting |
NCT05477680 -
Intraoperative Brain Shift Calculation Study
|
N/A | |
Recruiting |
NCT05484219 -
Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations
|
N/A | |
Completed |
NCT03656211 -
Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation
|
||
Completed |
NCT04246125 -
Patient Skin Dose in Interventional Radiology
|
||
Recruiting |
NCT02879071 -
Long Term Follow-up After Embolization of Brain Arteriovenous Malformations
|
||
Terminated |
NCT01801488 -
Genome-wide Analysis of Single Nucleotide Polymorphisms of Brain Arteriovenous Malformations and Cerebral Aneurysm
|
N/A | |
Recruiting |
NCT06259292 -
Comprehensive HHT Outcomes Registry of the United States (CHORUS)
|
||
Recruiting |
NCT02098252 -
Treatment of Brain AVMs (TOBAS) Study
|
N/A | |
Completed |
NCT02378883 -
Apollo™ Onyx™ Delivery Microcatheter Post Market Safety Study
|
N/A | |
Completed |
NCT00783523 -
Influence of MMP on Brain AVM Hemorrhage
|
Phase 1 | |
Recruiting |
NCT05276934 -
Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
|
||
Withdrawn |
NCT02079818 -
Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System
|
Phase 4 | |
Completed |
NCT01381952 -
Image Quality and Radiation Dose in Angiography
|
N/A | |
Active, not recruiting |
NCT05418816 -
SelfWrap-Assisted Arteriovenous Fistulas
|
N/A | |
Active, not recruiting |
NCT03559556 -
Treating Arteriovenous Malformation With Stereotactic Radiosurgery Using CT Angiography for Treatment Planning
|
Early Phase 1 |