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Acute Sleep Loss and Arterial Stiffness

Arterial Stiffness Clinical Trial

Official title:
Acute Sleep Loss and Arterial Stiffness

Clinical Trial Summary

The overarching goal of this study is to mimic a night shift work like schedule and characterize circadian variation in Pulse Wave Velocity (PWV), a measure of arterial stiffness, and determine the impact of acute loss of sleep like that experienced by shift workers on PWV.

Clinical Trial Description

Night shift work is associated with increased risk of cardiovascular disease (CVD). Pulse wave velocity (PWV) is a commonly used non-invasive measure of arterial stiffness and is strongly associated with CVD. Previous research links sleep loss, like that experienced by shift workers, to elevated levels or abnormal levels of PWV. In addition, there is some research that shows circadian variation in PWV, which has implications for future studies and when PWV should be assessed. The overarching goal of this study is to characterize circadian variation in PWV and determine the impact of acute loss of sleep on PWV during a schedule like that experienced by night shift workers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05940467
Study type Interventional
Source University of Pittsburgh
Contact
Status Terminated
Phase N/A
Start date July 11, 2023
Completion date May 30, 2024
View Details
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