Augmented Velocity Index of Intra-abdominal, Carotid and Retinal Arteries

Arterial Stiffness Clinical Trial

Official title:

Augmented Velocity Index of Intra-abdominal, Carotid and Retinal Arteries: In Relation to Arterial Stiffness and Cardiovascular Risk Factors.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05273905
• Other study ID #: 2022.3.1
• Status: Not yet recruiting
• Start date: May 2022
• Est. completion date: March 2025

Study information

• Verified date: March 2022
• Source: Chinese University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Background:

Augmented Velocity Index (Avi) is a new Doppler index which can potentially be used to assess arterial stiffness. The Avi of common carotid artery is found to be associated with arterial stiffness and have initial correlation with cardiovascular risk factors. Avi can be used in any vessels (superficial or deep vessels) where arterial Doppler waveforms can be obtained.

Aims:

The aims of this study are to investigate the associations of Avi of hepatic artery, renal artery, central retinal artery and internal carotid artery with arterial stiffness and cardiovascular risk factors in a group of apparently normal subjects.

Methods:

Recruit 350 subjects with no known medical illness or drug treatment for ultrasound examinations and blood tests. In ultrasound examination, the Avi of carotid arteries, hepatic arteries, renal arteries and retinal arteries are recorded. The carotid-femoral pulse wave velocity is also calculated for the assessment of central aortic stiffness.

Other important correlates of arterial stiffness including carotid intima-media thickness, fatty liver status, liver stiffness and abdominal fat thickness are assessed in the ultrasound examination.

The clinical and laboratory examinations include anthropometric indexes, plasma glucose level, lipid profile, renal function tests, liver function test, urinary albumin creatinine ratio, blood pressure measurement.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 350
• Est. completion date: March 2025
• Est. primary completion date: August 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Apparently healthy volunteers

Exclusion Criteria:

• Subjects with known medical illnesses including cancer, stroke, cardiovascular disease, diabetes, hypertension, dyslipidaemia, peripheral vascular disease, gout, systemic lupus erythematosus, psoriasis, rheumatoid arthritis and thyrotoxicosis.

• Subjects with long term drug use

Related Conditions & MeSH terms

• Arterial Stiffness

Intervention

Diagnostic Test:
• Ultrasound derived Avi
Assess the Avi of carotid arteries, hepatic arteries, renal arteries and central retinal arteries.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Augmented Velocity Index (Avi)	Avi of carotid, renal, hepatic and retinal arteries as recorded from the Doppler ultrasound waveforms of those arteries	Aug 2022 - May 2024
Secondary	Arterial wall thickness, liver stiffness and fatty liver status	Intima-media thickness of carotid artery is measured in gray scale ultrasound images; Liver stiffness is assessed by shear wave elastography of ultrasound technique; Fatty liver status is determined by the attenuation imaging of ultrasound	Aug 2022 - May 2024