Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients

Arterial Stiffness Clinical Trial

— AS  

Official title:

Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05155514
• Other study ID #: Arterial stiffness
• Status: Completed
• Start date: November 1, 2018
• Est. completion date: November 1, 2020

Study information

• Verified date: December 2021
• Source: Aydin Adnan Menderes University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.

In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 139
• Est. completion date: November 1, 2020
• Est. primary completion date: November 1, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• According to the American Society of Anesthesiologists (ASA), physical condition I-II,

• Elective otolaryngology surgery with endotracheal intubation planned

• Patients aged 50 and over

Exclusion Criteria:

• Hypersensitivity to drugs

• Difficult intubation history

• Diabetes mellitus receiving insulin therapy

• Chronic renal failure or end-stage renal disease

• Heart failure (left ventricular ejection fraction =30%)

• Valve disease (moderate to severe)

• Atrial fibrillation

Related Conditions & MeSH terms

• Arterial Stiffness

Intervention

Procedure:
• Mobil-O-Graph PWA
After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.

Locations

Country	Name	City	State
Turkey	Aydin Adnan Menderes University Faculty of Medicine, Department of Anesthesiology and Reanimation	Aydin

Sponsors (1)

Lead Sponsor	Collaborator
Aydin Adnan Menderes University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference between hemodynamic values	The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, =20% decrease in preoperative hemodynamic value and/or systolic blood pressure =90 mmHg hypotension, =20% increased hypertension	Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation