Arterial Disease Clinical Trial
Official title:
Dynamic Arterial Elastance: an Indirect Marker of the Critical Capillary Pressure at the Microcirculatory Level (POEME)
The measurement of dynamic arterial elastance (Eadyn) was proposed as a marker of vascular tone. It is calculated by the ratio of the respiratory variation of the pulse pressure and the respiratory variation of stroke volume. Despite several clinical studies, no study has really focused on the physiological significance of Eadyn. No study demonstrates at present, if this index is a reflect of macrocirculatory parameters (systemic resistances, blood pressure, arterial elastance, ventricular elastance, ventriculo-arterial coupling) or microcirculatory tone in the capillaries and small arterioles (critical capillary pressure or capillary resistance). the physicians don't know which variables are associated with this index. the hypothesis is that Eadyn is an indirect reflect of capillary pressure (PCC).
The measurement of dynamic arterial elastance (Eadyn) was proposed as a marker of vascular tone. It is calculated by the ratio of the respiratory variation of the pulse pressure and the respiratory variation of stroke volume. Despite several clinical studies, no study has really focused on the physiological significance of Eadyn. No study demonstrates at present, if this index is a reflect of macrocirculatory parameters (systemic resistances, blood pressure, arterial elastance, ventricular elastance, ventriculo-arterial coupling) or microcirculatory tone in the capillaries and small arterioles (critical capillary pressure or capillary resistance). the physicians don't know which variables are associated with this index. One hypothesis is that Eadyn is an indirect reflection of capillary pressure (PCC). The main objective of this project is to study the correlation between the measure of Eadyn and the PCC. The study begins when the physician in charge of the patient decides a hemodynamic treatment (either volume expansion or norepinephrine). The indication of the treatment is left to the discretion of the physician in charge of the patient: volume expansion or vasopressor agent. After verification of inclusion criteria, the physician collects demographic, ventilatory, hemodynamic, cardiac ultrasound data, and the type of treatment initiated (volume expansion, norepinephrine, and their dosages). 15 minutes after the introduction of the therapy and stabilization of the hemodynamic state, a new series of measurements of the aforementioned. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04511234 -
Sirolimus Coated Balloon Versus Standard Balloon for SFA and Popliteal Artery Disease
|
N/A | |
Completed |
NCT04359446 -
Laser-excimer Versus High-pressure Dilation to Treat Under-expansion of the Stent
|
N/A | |
Completed |
NCT04285411 -
Vital USA SpO2 Accuracy Comparison to Arterial Blood CO-Oximetry
|
N/A | |
Not yet recruiting |
NCT05554055 -
Correlation Between LR-ACT and Anti Xa Activity During Endovascular Surgery Procedures. AXAES (Anti Xa vs ACT-LR in Endovascular Surgery)
|
||
Completed |
NCT04651894 -
Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness
|
||
Active, not recruiting |
NCT04061798 -
ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.
|
Phase 4 | |
Recruiting |
NCT04428138 -
Inguinal Hernia and Arterial Disease
|
||
Withdrawn |
NCT01570803 -
Efficacy Between Different Two Self-Expanding Nitinol Stents For The Atherosclerotic Femoro-Popliteal Arterial Disease
|
N/A | |
Active, not recruiting |
NCT03970538 -
PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
|
N/A | |
Recruiting |
NCT03426293 -
Measuring the ACT During Non-cardiac Arterial Procedures.
|
||
Recruiting |
NCT04258046 -
Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation
|
Phase 2 | |
Recruiting |
NCT05054764 -
Promus PREMIER Below The Knee Registry
|