ARDS Clinical Trial
Official title:
Determine the Effect of Prone Positioning on Lung Ventilation and Perfusion Distribution in Adults With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography
NCT number | NCT04725227 |
Other study ID # | P-E |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | December 1, 2020 |
Est. completion date | December 31, 2022 |
determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2022 |
Est. primary completion date | December 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - patients who were undergoing mechanical ventilation with moderate-to-severe ARDS (defined as a Pao2:Fio2 ratio < 150 mm Hg with a positive end-expiratory pressure = 5 cm of water, and an Fio2 of = 0.6) according to the Berlin definition Exclusion Criteria: - contraindications to the use of EIT (e.g., presence of pacemaker or chest surgical wounds dressing) |
Country | Name | City | State |
---|---|---|---|
China | Zhongshan Hospital of Fudan University | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Zhongshan Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assess regional distribution of pulmonary perfusion | To evaluate the effect of prone positon on pulmonary blood flow distribution. | within 24 hours | |
Primary | Assess regional distribution of pulmonary ventilation | To evaluate the effect of prone positon on pulmonary vetilation distribution. | within 24 hours | |
Primary | Assess oxygenation status | To evaluate the effect of prone position by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated. | within 24 hours |
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