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ARDS clinical trials

View clinical trials related to ARDS.

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NCT ID: NCT04737486 Completed - Covid19 Clinical Trials

A First-in-Human Study of AV-001 in Healthy Subjects

Start date: December 16, 2020
Phase: Phase 1
Study type: Interventional

Phase 1 randomized, double-blind, placebo-controlled single ascending dose (SAD) and multiple ascending dose (MAD) first-in-human study in healthy subjects. Safety and tolerability assessments will be conducted, and blood samples will be taken pre-dose and at several time points post-dose for pharmacokinetic (PK) and pharmacodynamics (PD) analysis.

NCT ID: NCT04710173 Completed - ARDS Clinical Trials

Establishment of a Early Risk Model of ECMO in Children With ARDS

Start date: January 1, 2018
Phase:
Study type: Observational

The key problem in the treatment of ARDS is refractory hypoxemia. Extracorporeal Membrane Oxygenation (ECMO) is an extracorporeal oxygenation of venous blood to eliminate carbon dioxide and return to the body. It has been an important part of the rescue treatment for ARDS. This study intends to explore the timing of ECMO. The main research hypothesis is that the appropriate timing of ECMO treatment can improve the weaning success rate and survival rate of children with severe ARDS; it is expected to provide a basis for determining the best timing of ECMO treatment

NCT ID: NCT04694638 Completed - Covid19 Clinical Trials

Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection

Start date: May 21, 2020
Phase: N/A
Study type: Interventional

This research aims to understand if prone positioning combined with high-flow nasal cannula (HFNC) or non-invasive positive pressure ventilation (NIPPV) safely reduce the rate of intubation in acute hypoxemic and/or hypercapnic respiratory failure secondary to COVID-19 infection.

NCT ID: NCT04692779 Completed - Covid19 Clinical Trials

A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients

Start date: January 31, 2021
Phase:
Study type: Observational

The proposed study will be conducted to investigate the mechanism of patients' responses to prone positioning with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) and non-COVID-19 ARDS utilizing lung ultrasound.

NCT ID: NCT04667923 Completed - Covid19 Clinical Trials

Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome

COVID-NIV
Start date: October 1, 2020
Phase:
Study type: Observational

Non-invasive ventilation can allow to avoid intubation and improve outcomes in moderate-to-severe COVID-19-associated acute respiratory distress-syndrome (ARDS). Data on NIV parameters adjustment based on expanded respiratory and gas exchange monitoring in COVID-19 associated ARDS is limited. Appropriate adjustment of the inspiratory positive airway pressure (IPAP) set as a point of the balance between minimal work of breathing (minimum point of W.Patrick scale for assessment of the accessory respiratory muscles and minimum diaphragm thickening fraction) and minimum tidal volume, and respiratory rate can decrease NIV failure in moderate-to-severe COVID-ARDS. The objective of the study is to evaluate the ability of non-invasive ventilation guided with expanded respiratory monitoring to decrease the intubation rate in in moderate-to-severe COVID-ARDS.

NCT ID: NCT04663802 Completed - Critical Illness Clinical Trials

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study

INPUT
Start date: February 22, 2021
Phase: N/A
Study type: Interventional

This study is a large pragmatic stepped-wedge trial of electronic health record (EHR)-based implementation strategies informed by behavioral economic principles to increase lung-protective ventilation (LPV) utilization among all mechanically ventilated (MV), adult patients. The study will compare the standard approach to managing MV across 12 study Intensive Care Units (ICUs) within University of Pennsylvania Health System (UPHS) versus interventions prompting physicians and respiratory therapists (RTs) to employ LPV settings promote LPV utilization among all MV patients.

NCT ID: NCT04663555 Completed - Covid19 Clinical Trials

Effect of Two Different Doses of Dexamethasone in Patients With ARDS and COVID-19

REMED
Start date: February 2, 2021
Phase: Phase 4
Study type: Interventional

REMED is a prospective, phase II, open-label, randomised controlled trial testing superiority of dexamethasone 20 mg vs 6 mg. The trial aims to be pragmatic, i.e. designed to evaluate the effectiveness of the intervention in conditions that are close to real-life routine clinical practice. The study is multi-centre and will be conducted in the intensive care units (ICUs) of ten university hospitals in the Czech Republic. This is an open-label trial in which the participants and the study staff will be aware of the allocated intervention. Blinded pre-planned statistical analysis will be performed.

NCT ID: NCT04659109 Completed - COVID-19 Clinical Trials

Glenzocimab in SARS-Cov-2 Acute Respiratory DistrEss syNdrome Related to COVID-19

GARDEN
Start date: December 16, 2020
Phase: Phase 2
Study type: Interventional

A randomized, double blind, multicenter, placebo-controlled, parallel group, fixed dose, phase II study to evaluate the efficacy and safety of glenzocimab in ARDS.

NCT ID: NCT04653831 Completed - Covid19 Clinical Trials

Treatment With Pirfenidone for COVID-19 Related Severe ARDS

Start date: November 8, 2020
Phase: N/A
Study type: Interventional

A randomized, open label, two arm, pilot trial of Pirfenidone 2,403 mg administered per nasogastric tube or orally as 801mg TID for 4 weeks in addition to Standard of Care (SoC), compared to SoC alone, in a population of COVID-19 induced severe ARDS. Patients will be randomized according to 1:1 ratio to one of the trial arms: Pirfenidone (intervention arm) or SoC (control arm).

NCT ID: NCT04641182 Completed - Covid19 Clinical Trials

Prone Position for Nonintubated Patients With COVID-19 and Hypoxemic Respiratory Failure

Start date: July 6, 2020
Phase:
Study type: Observational [Patient Registry]

The aim of this observational study is to evaluate the physiological and clinical effects of prone position in awake patients with respiratory failure due to COVID-19.