Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Appendicitis Clinical Trial

Official title: Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Status Recruiting

Clinical Trial Summary

The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.

Clinical Trial Description

Complicated appendicitis with abscess or phlegmon represents a challenging problem to emergency general surgeons, and the preferred treatment remains controversial. A variety of therapies have been recommended including early operative intervention, delayed operative intervention, and non-operative management. Recently, a prospective randomized controlled trial from a single center was conducted in Finland comparing operative and non-operative management of appendiceal abscess. Patients managed in the operative arm were found to have a shorter length of stay, fewer re-admissions, and fewer additional interventions than those managed in the non-operative group, but there is no high-quality randomized control trial conducted in the United States to support this. The investigators, therefore plan to carry out a multi-center, patient choice study comparing operative and non-operative management of complicated appendicitis with abscess or phlegmon in the United States. ;

Related Conditions & MeSH terms

• Appendicitis

• NCT number: NCT04168866
• Study type: Interventional
• Source: Yale University
• Contact: Kevin Schuster, MD, MPH
• Phone: 203 785 2572
• Email: kevin.schuster@yale.edu
• Status: Recruiting
• Phase: N/A
• Start date: March 11, 2020
• Completion date: December 31, 2026