Postoperative Complications After Appendectomy

Appendicitis Clinical Trial

Official title:

Clinical Value of Postoperative C-reactive Protein in the Detection of Complications After Open and Laparoscopic Appendectomy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03119740
• Other study ID #: APPCO-017
• Status: Completed
• Start date: August 1, 2016
• Est. completion date: November 30, 2016

Study information

• Verified date: October 2023
• Source: Kepler University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The frequency of complications after appendectomy is about 9% . The predictive value of CRP as an indicator of postoperative complications has been addressed in a small number of studies. The aim of the present retrospective analysis was to determine whether postoperative CRP levels are a reliable predictor of postoperative complications.

Description:

Background: Acute appendicitis is a common emergency in general surgery. The frequency of complications after appendectomy is about 9% [9]. The predictive value of CRP as an indicator of postoperative complications has been addressed in a small number of studies. The aim of the present retrospective analysis was to determine whether postoperative CRP levels are a reliable predictor of postoperative complications.

Methods: This retrospective single-center cohort study comprised 744 patients who had undergone open or laparoscopic appendectomy for clinically suspected appendicitis between 1 January 2011 and 31 December 2015 at the department of general and visceral surgery, Kepler University Hospital in Linz, Austria. Demographic data, the surgical technique, postoperative complications, histopathological findings, postoperative white blood counts, and C-reactive protein levels were evaluated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 744
• Est. completion date: November 30, 2016
• Est. primary completion date: October 30, 2016
• Gender: All
• Age group: 18 Years to 96 Years

Eligibility

Inclusion Criteria:

• clinically suspected appendicitis between 1 January 2011 and 31 December 2015

Exclusion Criteria:

• an elective appendectomy as part of an oncological or gynecological operation tumor was found intraoperatively and required ileocecal resection or right hemicolectomy

Related Conditions & MeSH terms

• Appendicitis

Locations

Country	Name	City	State
Austria	Clinic for General and Visceral Surgery, Kepler University Clinic Linz	Linz	Upper Austria

Sponsors (1)

Lead Sponsor	Collaborator
Kepler University Hospital

Country where clinical trial is conducted

Austria, 

References & Publications (3)

Barkhausen S, Wullstein C, Gross E. [Laparoscopic versus conventional appendectomy--a comparison with reference to early postoperative complications]. Zentralbl Chir. 1998;123(7):858-62. German. — View Citation

Izbicki JR, Knoefel WT, Wilker DK, Mandelkow HK, Muller K, Siebeck M, Schweiberer L. Accurate diagnosis of acute appendicitis: a retrospective and prospective analysis of 686 patients. Eur J Surg. 1992 Apr;158(4):227-31. — View Citation

Kaya B, Sana B, Eris C, Karabulut K, Bat O, Kutanis R. The diagnostic value of D-dimer, procalcitonin and CRP in acute appendicitis. Int J Med Sci. 2012;9(10):909-15. doi: 10.7150/ijms.4733. Epub 2012 Nov 13. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	superficial wound infection	superficial wound infection in open and laparoscopic appendectomy	4 weeks postoperative
Secondary	intraabdominal abscess	intraabdominal abscess in open and laparoscopic appendectomy	4 weeks postoperative
Secondary	ileus	ileus in open and laparoscopic appendectomy	4 weeks postoperative