Conservative Versus Operative ManageMent of Acute Uncomplicated

Status Completed

Clinical Trial Summary

This study aims to compare antibiotic treatment versus surgery for patients with uncomplicated appendicitis.

Clinical Trial Description

The study will include patients aged 16 and over, with a first admission with right iliac fossa pain and a raised white cell count or C-reactive protein. Patients will be randomised electronically in a 1:1 ratio either to undergo emergency appendectomy or to receive intravenous antibiotics as an inpatient, until clinical and biochemical improvement is observed, followed by outpatient oral antibiotics. Those who have surgery will have 3 post-operative doses of intravenous antibiotics, unless perforation was identified at the time of surgery, in which case, microbiology will be contacted to advise regarding antibiotic choice and duration. Follow-up by telephone interview will be at 1 week, 1, 3 and 12-month intervals. ;

Study Design

Related Conditions & MeSH terms

Appendicitis

Clinical Trial Details

NCT number	NCT02916134
Study type	Interventional
Source	Beaumont Hospital
Contact
Status	Completed
Phase	N/A
Start date	September 12, 2016
Completion date	December 8, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04529980` - Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis	N/A
Withdrawn	`NCT03528343` - Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy	Phase 1/Phase 2
Recruiting	`NCT03522233` - Pediatric Appendicitis Risk Calculator (pARC) in Children With Appendix Ultrasounds
Recruiting	`NCT03380793` - A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis	Phase 4
Recruiting	`NCT02108340` - Comparative Study of Microwave Radiometry and Ultrasonography for the Diagnosis of Acute Appendicitis	N/A
Terminated	`NCT02029781` - The Laparoscopic Appendicitis Score; a Multicenter Validation Study	N/A
Completed	`NCT01356641` - Antibiotic Treatment Alone for Acute Simple Appendicitis in Children	N/A
Terminated	`NCT00971438` - Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging	N/A
Completed	`NCT00913380` - Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT	Phase 3
Completed	`NCT01515293` - Single Incision Versus Conventional Laparoscopic Appendectomy	Phase 3
Completed	`NCT00530998` - Minimally Invasive Surgery: Using Natural Orfices
Completed	`NCT00616616` - Single Incision Laparoscopy	N/A
Completed	`NCT00195351` - Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection	Phase 4
Completed	`NCT04614649` - Right Iliac Fossa Treatment-Turkey Audit
Completed	`NCT04365491` - European Society for Trauma and Emergency Surgery (ESTES) Cohort Study Snapshot Audit 2020 - Acute Appendicitis
Completed	`NCT03770897` - Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome	N/A
Completed	`NCT02507674` - Point of Care 3D Ultrasound for Pediatric Appendicitis: a Pilot Study
Active, not recruiting	`NCT01718275` - Non-operative Management of Early Appendicitis in Children
Terminated	`NCT01575028` - Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies	Phase 2
Completed	`NCT01734837` - TICAP - Titanium Clips for Appendiceal Stump Closure	N/A

Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis — COMMA

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms