Appendicitis Clinical Trial
Official title:
Laparoscopic Appendectomy for Uncomplicated Appendicitis: Does Antimicrobial Prophylaxis Really Matter? Randomized Control Trial
To compare surgical site infection (SSI) rate in patients undergoing laparoscopic appendectomy for acute uncomplicated appendicitis and treated with single dose regime of antibiotics versus group of patients undergoing laparoscopic appendectomy without antibiotics treatment. Patient will be given either single dose of perioperative antibiotics or no antibiotics before surgery.
Laparoscopic appendectomies are performed by one of the 6 institutional attending surgeons.
US and/or abdominal CT scans are obtained as clinically necessary to make the diagnosis of
appendicitis. All of the appendectomies are initiated laparoscopically. Postoperative orders
are controlled via a standard electronic order set for all operations.
Patients found to have acute uncomplicated appendicitis at appendectomy will be randomized
to either single dose of perioperative antibiotics /On the second post-operative day the
patient who has no fever and tolerating a regular diet, will be discharged home without oral
antibiotics. On the post-operative, day seven after surgery all patients will be examined in
the outpatient clinic on the presence of surgical site infection. then will be followed for
a 30 days after surgery .
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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