Low vs. Standard Dose CT for Appendicitis Trial — LOCAT  

Appendicitis Clinical Trial

Official title: A Multi-institutional Trial Comparing Clinical Outcomes Following Low- vs. Standard-dose Abdominal CT as the First-line Imaging Test in Adolescents and Young Adults With Suspected Acute Appendicitis

Status Completed

Clinical Trial Summary

To determine whether low-dose (LD) CT is noninferior to standard-dose (SD) computed tomography (CT) as the first-line imaging test in adolescents and young adults in regard to negative appendectomy rate (NAR).

Clinical Trial Description

• Acute appendicitis is a very common disease. Many patients are adolescents or young adults.

• CT is the current standard imaging test for the diagnosis of appendicitis.

• In recent years, the awareness of carcinogenic risk associated with CT radiation has increased.

• According to a recent single-institutional randomized controlled trial, LD CT (employing a quarter of standard radiation dose) was found to be noninferior to SD CT with respect to NARs in adolescents and young adults with suspected appendicitis.

• However, LD CT is not yet widely accepted.

• To establish LD CT as the first-line imaging test, a multi-institutional study is needed to confirm the generalizability of the prior single-institutional study. ;

Related Conditions & MeSH terms

• Appendicitis

• NCT number: NCT01925014
• Study type: Interventional
• Source: Seoul National University Bundang Hospital
• Status: Completed
• Phase: N/A
• Start date: December 2013
• Completion date: February 2017