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Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA

Aplastic Anemia Clinical Trial

Official title:
Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA

Clinical Trial Summary

The haplotype HSCT system including Bu(0.8mg/kg Q6hx2d)CTX(50mg/kgx4d)rATG(2.5mg/kgx4d) , established in Institute of Hematology of Peking University ,has been evaluated to be effective for acquired SAA.But some patients with high risk factors may not tolerate CTX 200mg/kg,alternative conditioning regimen including Bu/Fludarabine/dercreased CTX was studied in this trial.

Clinical Trial Description

Patients enrolled in this study would receive Bu (IV)0.8mg/kg Q6hx2d,Fludarabine 30mg/m2x5d ,CTX(cyclophosphamide) 25mg/kg/dx4d,rATG (thymoglobulin,Sang Stat,France) 2.5mg/kg/dx4d.

BM or Blood samples from patients were obtained to assess engraftment and chimerism after HSCT. The time point that investigators monitor BM or blood samples at 1 month,2 months, 3 months,6 months, 9 months and 1year,2years,3years 5 years after HSCT. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03821987
Study type Interventional
Source Peking University People's Hospital
Contact Xiaojun Huang, Prof.
Phone 861088326006
Email lpxu_0415@sina.com
Status Recruiting
Phase N/A
Start date December 17, 2018
Completion date March 30, 2022
View Details
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