Aphasia Clinical Trial
Official title:
Transcranial Direct Current Stimulation Investigations of Language Processing in Aphasia
This study proposes to use transcranial direct current stimulation (tDCS) in patients with chronic strokes and aphasia in order to characterize and enhance the mechanisms of language recovery following injury. Prior to enrollment subjects will undergo six "site-finding' sessions involving various placements of positively charged (anodal), negatively charged (cathodal), and sham stimulation over the damaged and intact hemispheres of the brain, along with standard tests of language. Subjects who are found to experience a transient improvement in language ability in this initial experiment will participate in an incomplete cross-over design study to determine if 10 sessions of tDCS stimulation lead to prolonged language benefit when delivered to the hemisphere and at the polarity shown previously to respond best to stimulation.
Transcranial Direct Current Stimulation (tDCS) uses a small (typically 1-2 mA) electrical
current which is passed through the scalp and is delivered for up to 20 minutes. Due to the
safety and tolerability of tDCS, as well as its demonstrated capacity to temporarily enhance
cognitive, motor and affective functions of the brain, there has been an explosion of
interest in the technique since the first reports in 2000. tDCS has been used safely in a
wide variety of domains including studies of the visual system, working memory, verbal
fluency and motor function. tDCS has also been used safely to enhance brain function in
subjects with a variety of brain pathologies including stroke, depression and Alzheimers
Disease. In this study, the investigators hope to address whether tDCS can be used to enhance
language function in individuals with post-stroke aphasia.
This two part experiment will address 1) Can tDCS lead to transient improvement in language
ability in individuals with stroke and chronic aphasia? and 2) Does repeated tDCS lead to
prolonged improved language ability in individuals with stroke and chronic aphasia?
In Experiment 1, which will be referred to as the 'site-finding' portion of this protocol,
participants will undergo anodal, cathodal, and sham stimulation of the intact or injured
hemisphere to determine what area of the brain responds best to tDCS. There will be six
separate sessions which are spaced apart by at least 2 days. Tests of language will be used
to characterize changes in performance that are induced in each condition.
In Experiment 2, subjects who had participated in Experiment 1 and were found to experience a
transient improvement in language ability after receiving tDCS will participate. Subjects
will be stimulated using the best montage from Experiment 1. This is an incomplete cross-over
design study to determine if 10 sessions of tDCS stimulation delivered to the brain will lead
to improvement in language. Improvement will be operationally defined as performance on one
or more language measures that is significantly better than baseline and sham performance
(i.e. non-stimulation conditions). Half of our subjects will be randomized to a group
receiving 10 sessions (divided in to two five-day periods) of real tDCS. The other half of
our subjects will be randomized to undergo sham stimulation before undergoing optional real
tDCS stimulation. All subjects will engage in language rehearsal during stimulation. Tests of
language will be used to characterize changes in performance that are induced by real and
sham stimulation. Follow-up language testing will be performed at 2 weeks and 2 months after
stimulation to determine whether tDCS can have prolonged effects on language.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03622411 -
Tablet-based Aphasia Therapy in the Chronic Phase
|
N/A | |
| Recruiting |
NCT03605381 -
MORbidity PRevalence Estimate In StrokE
|
||
| Recruiting |
NCT03929432 -
Treatment Outcomes With tDCS in Post-Stroke Aphasia
|
N/A | |
| Completed |
NCT03662295 -
Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention
|
||
| Completed |
NCT03679637 -
Tablet-based Aphasia Therapy in the Acute Phase After Stroke
|
N/A | |
| Completed |
NCT03550092 -
Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia
|
N/A | |
| Completed |
NCT03228264 -
A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.
|
N/A | |
| Suspended |
NCT04290988 -
Circuitry Assessment and Reinforcement Training Effects on Recovery
|
N/A | |
| Recruiting |
NCT05969548 -
pBFS-guided cTBS at Different Doses for Aphasia After Stroke
|
N/A | |
| Recruiting |
NCT04138940 -
Modulating Intensity and Dosage of Aphasia Scripts
|
N/A | |
| Terminated |
NCT02249819 -
Evaluating Anodal tDCS Preceding Aphasia Therapy
|
Phase 1/Phase 2 | |
| Completed |
NCT01654029 -
Patient Centred Communication Intervention
|
N/A | |
| Completed |
NCT00843427 -
fMRI of Language Recovery Following Stroke in Adults
|
N/A | |
| Active, not recruiting |
NCT00227461 -
Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients.
|
Phase 1 | |
| Completed |
NCT03773419 -
Improving Electronic Written Communication in Aphasia
|
N/A | |
| Not yet recruiting |
NCT04142866 -
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
|
N/A | |
| Suspended |
NCT04048668 -
tDCS to Treat Subacute Aphasia
|
N/A | |
| Recruiting |
NCT04081207 -
Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia
|
N/A | |
| Completed |
NCT02226796 -
Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia
|
N/A | |
| Completed |
NCT01163461 -
Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia
|
N/A |