Clinical Trials Logo

Clinical Trial Summary

The aim of this research is to translate a theory of the cognitive relationship between verbal short--term memory (STM) and word processing impairments in aphasia to treatment approaches for language impairment in aphasia. It has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. This hypothesis will be tested in the context of a treatment approach that aims to improve word processing and verbal STM abilities. The grant supporting this work has ended. therefore, participants are entered into the study by invitation only.


Clinical Trial Description

Based on research of word processing and verbal STM impairments in aphasia, it has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. This hypothesis will be tested in the context of a treatment approach that aims to improve word processing and verbal STM abilities. Recently, the importance of treatment research has been emphasized as a critical testing ground for theories of language processing. Although it has been demonstrated that associations between impairments of word processing and reduced verbal STM capacity support the 'activation-maintenance hypothesis', direct treatments to improve the ability to maintain activation of word representations will serve as a stronger test of this hypothesis. First, empirical support will be established for the hypothesis that impairment to short-term maintenance of activated semantic and phonological representations of words impairs language and verbal STM abilities in aphasia and that direct treatment of this deficit will improve both abilities (Specific Aim 1). Second, the effects of this treatment will be compared under two administration conditions, high and low intensity (Specific aim 2). Finally, the neural regions associated with semantic STM and phonological STM will be investigated using voxel--based lesion--symptom mapping (Bates et al., 2003) (Specific Aim 3). This research represents a unique attempt to apply more recent processing theories of aphasia to treatment of the disorder.The outcomes will have important implications for aphasia rehabilitation research. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02664506
Study type Interventional
Source Temple University
Contact
Status Enrolling by invitation
Phase N/A
Start date March 2014
Completion date November 30, 2025

See also
  Status Clinical Trial Phase
Completed NCT03622411 - Tablet-based Aphasia Therapy in the Chronic Phase N/A
Recruiting NCT03605381 - MORbidity PRevalence Estimate In StrokE
Recruiting NCT03929432 - Treatment Outcomes With tDCS in Post-Stroke Aphasia N/A
Completed NCT03662295 - Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention
Completed NCT03679637 - Tablet-based Aphasia Therapy in the Acute Phase After Stroke N/A
Completed NCT03550092 - Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia N/A
Completed NCT03228264 - A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia. N/A
Suspended NCT04290988 - Circuitry Assessment and Reinforcement Training Effects on Recovery N/A
Recruiting NCT05969548 - pBFS-guided cTBS at Different Doses for Aphasia After Stroke N/A
Recruiting NCT04138940 - Modulating Intensity and Dosage of Aphasia Scripts N/A
Terminated NCT02249819 - Evaluating Anodal tDCS Preceding Aphasia Therapy Phase 1/Phase 2
Completed NCT01654029 - Patient Centred Communication Intervention N/A
Completed NCT00843427 - fMRI of Language Recovery Following Stroke in Adults N/A
Active, not recruiting NCT00227461 - Levetiracetam (Keppra) to Improve Chronic Aphasia in Post-stroke Patients. Phase 1
Completed NCT03773419 - Improving Electronic Written Communication in Aphasia N/A
Not yet recruiting NCT04142866 - Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia N/A
Suspended NCT04048668 - tDCS to Treat Subacute Aphasia N/A
Recruiting NCT04081207 - Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia N/A
Completed NCT02226796 - Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia N/A
Completed NCT01163461 - Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia N/A