Aphasia, Acquired Clinical Trial
Official title:
Towards a Clinical Test Battery for the Assessment of Verbal Short-term Memory Abilities With Linguistic Variations in Patients With Poststroke Aphasia.
NCT number | NCT06068296 |
Other study ID # | BC-08865 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | April 30, 2023 |
Est. completion date | April 30, 2023 |
Verified date | September 2023 |
Source | University Hospital, Ghent |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Background and aim There is a growing awareness that people with aphasia (language problems) after a stroke often have difficulties with their short-term memory (STM). As a result, the explanation underlying aphasia has recently been seen as a language processing disorder, where multiple cognitive processes interact. To evaluate the cognitive processes underlying aphasia, there is a need for reliable and valid assessment tools. However, the quality of tests usually used to assess STM problems in aphasia patients is questioned because they are not specifically designed to be used in aphasia patients. This raises some concern, as impairments of STM can be predictive for the recovery and rehabilitation of aphasia patients. As an important exception, a recent study has developed a new English evaluation tool (i.e., The Temple Assessment of Language and (Verbal) Short-term Memory in Aphasia; TALSA) that examines language and STM aspects specifically developed for persons with aphasia. However, the existence of a Dutch evaluation tool specifically designed to assess language and STM problems in people with aphasia after a stroke is lacking. Therefore, the aim of the current study is to develop a Dutch clinical version of the TALSA battery that may lead to better diagnosis and treatment of STM problems in persons with aphasia. The development of the test focuses on its clinical feasibility (e.g. test duration, difficulty of the items and response modality). Pilot testing of the Dutch STM assessment instrument in the clinical and healthy population is very important to adapt the test where necessary. In addition, the quality of the test should also be carefully evaluated. Method The first step towards the development of a Dutch STM assessment instrument is the careful selection of the most crucial subtests of the original TALSA battery. Not all subtests will be selected due to the long testing time of the TALSA battery, and as mentioned earlier, the Dutch STM assessment tool focuses on clinical feasibility of the test. The second step is pilot testing the Dutch STM assessment instrument in persons with aphasia and healthy persons. Persons with aphasia will be recruited at the Stroke unit of Ghent University Hospital. All eligible patients will be asked to provide written informed consent to participate in this study. Three tests will be administered, namely the Oxford Cognitive Screen, the Token Test and the Dutch STM assessment tool. It is important that these tests are taken on the same day or on two consecutive days, depending on the circumstances (e.g. fatigue). The Token Test and Oxford Cognitive Screen provide a picture of the patient's cognitive profile. Throughout the process of pilot testing, the Dutch STM assessment tool will be adapted and improved where necessary. In order to verify or adjust the difficulty of the items, it is crucial that the STM assessment instrument is also tested on a small number of healthy control subjects (recruited via social media platforms).
Status | Completed |
Enrollment | 9 |
Est. completion date | April 30, 2023 |
Est. primary completion date | April 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria aphasia patients: - Aphasia after an initial ischemic or hemorrhagic stroke diagnosed by the speech pathologist and a screening instrument to evaluate aphasia (ScreeLing) - Age 18-85 years - Speak Dutch as a mother language - Acute to subacute phase poststroke - Imaging (CT/MRI) is available prior to inclusion - Signed informed consent Exclusion Criteria aphasia patients: - There is a history of other diseases of the central nervous system causing non-stroke related speech-, language or cognitive disorder - They present severe sensory impairment or other co-morbidities prohibiting administration of the assessment tool - Excessive active alcohol or drug abuse - Transient ischemic attack (i.e., TIA) Inclusion Criteria healthy participants: - Normal score (> 26) on the Montreal Cognitive Assessment (MOCA) - Speak Dutch as a mother language Exclusion Criteria aphasia patients: - Have no history of stroke or other central nervous system diseases that affect speech, language or cognition - Have no severe auditory or visual disorders |
Country | Name | City | State |
---|---|---|---|
Belgium | Ghent University Hospital | Ghent | East Flanders |
Belgium | University Hospital Ghent | Ghent |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Ghent |
Belgium,
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* Note: There are 18 references in all — Click here to view all references
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---|---|---|---|---|
Primary | verbal short-term memory in poststroke aphasia | assessment of verbal short-term memory in patients with poststroke aphasia: feasability, psychometric properties and normative data | 2 hours |
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